It is the 24th Century, where the survivors of a nuclear war live within a domed city sealed off from the outside world, where all citizens can only live until they are 30 years. Logan, a Sandman, an elite policeman whose job is to terminate all runners who refuse to die at 30 in the extermination ceremony "Carousel", begins to question the system. Logan and a woman named Jessica leave the city to go in search of the mysterious place "Sanctuary". They stumble upon a mountain city ruled by Draco and Siri and meet Rem, an android who decides to join them in their search...
Logan and Jessica are abducted by John the Protector and Joanna, aliens from another planet where like other Runners they've abducted, are manipulating their minds, making them believe that they have found Sanctuary. Will Logan and Jessica escape and free the captive Runners?
James Borden, a hunter captures, Logan, Jessica, Rem and Francis, after Francis captures the three runners. Where Borden decides to free Logan and Francis and he decides to hunt them like animals, where Logan and Francis decides to join forces and set out to rescue Jessica and Rem from Borden. Can Logan and Francis save Jesscia and Rem?
Logan, Jessica and Rem encounter a young woman named Lisa whose parents left her alone along with two robots for company. Where Lisa has a crush on Logan where she plans to get rid of Jessica, so she can have Logan for herself.
David Eakins, a scientist time travels 200 years into the future, where he encounters Logan, Jessica and Rem, where he plans to change history and prevent the nuclear war. Can Logan, Jessica and Rem stop David from changing history?
Logan, Jessica and Rem are attacked by two bands of duplicate humans with vastly different temperaments. One group is kind and gentle, while the other is violent and vicious. Jessica is captured and split into two different people with completely opposite temperaments.
The runners find an underground room with six survivors of the nuclear holocaust cryogenically frozen. A series of earthquakes complicate efforts to rescue the frozen humans.
A Sandman has plastic surgery so that he appears identical one of Jessica's friends. In this form he convinces the runners to return to the City of the Domes to supposedly assist other runners escape to the outside world.
Logan and Jessica are kidnapped by a woman named Ariana who uses a dream analyzer of them. Logan dreams he is back in the domed city and he is being interrogated by the Sandmen about how he found Sanctuary and Jessica dreams she is being forced to take part on Carousel by a sinister man who forces her to wear a mask. Unaware Francis and a Sandman have arrived to apprehend Logan and Jesscia and Arianna isn't what she seems.
Logan is shot by Francis, with a dart containing a serum which erases his memory, Francis takes Logan back to the domed city, where Logan is to be terminated on Carousel for his actions. Where Jessica and Rem returns to the Domed city to rescue Logan, who cannot remember Jessica and Rem and has loss of memory of the previous year. Can Jessica and Rem save Logan from being terminated on Carousel? and will Logan's memories be revived?
The runners stop at a house haunted by devil-worshiping ghosts. Jessica is captured so one of the phantoms can use her as the receptacle for his dead wife's spirit.
Logan, Jessica and Rem encounters alien natives from a planet where the the temperatures are much hotter than Earth that have arrived on Earth. Where they require from Rem, his parts so they can repair their spaceship. Can Logan and Jessica save Rem from being dismantled?