After the duo fail to capture a wanted felon, Hutch bets that he can successfully elude Starsky for 48 hours. The game becomes deadly serious when Starsky discovers that Hutch has unknowingly eaten soup contaminated with botulism.
Starsky unknowingly places himself in serious danger when the Detectives investigate a woman's claims that a jealous ex-lover from San Francisco has followed her and is responsible for the murders of her recent one-night stands.
A top model believes she has terminal cancer and arranges for a genius hit-man to end her life. She discovers the cancer is in remission, but it is too late to cancel the contract, so she turns to old flame Hutch to prevent her own death.
Starsky's little brother, a smalltime hustler, arrives in town to visit Starsky. He's approached by the mob and he thinks he's become a big fish until he gets caught up in a net he can't get out of without Starsky's help.
The series finale: James Michael Gunther, the businessman who was the lead villain in "Targets Without a Badge" two shows earlier, returns to put out a murder contract on Dave Starsky. Starsky is critically wounded and seems to be dying. Hutchinson wants revenge, but can't seem to find Gunther -- until Gunther unexpectedly hands him a present -- the corpse of his own lawyer Bates in Gunther's office.