The boys are tasked with investigating Playboy Island. The island is owned by billionaire William Thorne, and a series deaths have attracted the attention of the authorities. They believe the appearance of Johnny Doors, a high ranking crime syndicate figure may indicate an attempt to take over the financial empire by the Mob.
Starsky's childhood mentor, Police Lt. John Blaine, is found dead under compromising circumstances, and Starsky and Hutch need to contend with their preconceptions about homosexuality as they try to solve the homicide.
When their schoolteacher friend, Carol Wade, discovers a terrible secret about one of her students, she turns to Starsky and Hutch for help. They learn about the challenges facing the Child Abuse Unit.
Reporter Chris Phelps rides along with Starsky and Hutch in order to research an article on "the counter-culture cops, the new breed," as they investigate pushers that are cutting their drugs with strychnine.
Lt. Jake Donner dies of a mysterious, highly contagious virus a few days after returning from Europe. Starsky and Hutch try to hunt down the only patient who has survived the disease, as he holds the only possibility of a cure. Unfortunately, he is an international hit man who does not want to be found.
As Hutch fights for his life when quarantined with a deadly virus, Starsky continues the search for the only hope of a cure, an elusive hit man who recovered from the disease. Starsky even confronts the hit man's target and turns to the media for help.
When a black man who's a friend of Starsky and Hutch is shot by a cop who tries to cover up by lying. When a witness says he's lying he reveals himself to be a racist. The man's son so upset that his father died and that the man who killed him will probably not be punished, wants to get away so he turns to a friend who's a punk, to get money. The guy convinces him the best way to get is to rob the pharmacy at the hospital where Dr. Sammie Mason works.
Due to threats on her life, Starsky and Hutch are assigned to protect a visiting Russian ballerina. Hutch, a big fan, is impressed by her talent, but disappointed with her bristling personality as they get off on the wrong foot.
A weekend trip to Captain Dobey's cabin turns sinister for Starsky & Hutch when they discover a cult across the lake and try to determine why the sheriff and inhabitants of the nearby small town are treating them so strangely.
During a high-speed chase, Starsky's reckless driving lands the partners in the hospital, where Hutch appears to be stricken with amnesia. Starsky attempts to revive Hutch's memory by reminding him of their past adventures.
A serial killer who preys on prostitutes is wounded during his latest attack. When he takes Hutch's friend and her invalid mother hostage in their home, Hutch poses as a paramedic to get inside the house.