Bill Hader makes his hosting debut alongside musical guest Hozier. Sketches include Herb Welch: Virginity Pledge Rally, YA Trailer, Hollywood Game Night, Weekend Update: Stefon Returns, Puppet Class and Cat.
Sketches include "Bush Addresses the Nation", "Morgan Stanley", "The JetBlue Crisis", "Anderson Cooper 360", "The Couple That Should Be Divorced", "Girls Gone Wild Katrina", "Kanye Backstage", "The Lundford Twins Variety Hour", "Fun With Real Audio", and "Debbie Downer". Kanye West performs "Gold Digger" and "Heard 'Em Say" featuring Adam Levine.
Natalie Portman hosts this episode and Fall Out Boy is the musical guest. The Cold Opening is a Message from President George W. Bush(Will Forte) who addresses the public on issues of secret White House activity and Vice-President Dick Cheney's(Darrell Hammond) hunting accident. Natalie Portman's Monologue consists of her tackling questions raised by "Star Wars" nerds in the audience. Repeat of Nelson Baby Toupees commercial from January 21, 2006, which spoofs Hair Club For Men commercials. Three over-psyched Jamba Juice employees (Portman, Seth Meyers, Horatio Sanz),...
Spring Break Cold Opening, Matt Dillon Monologue, Doppelganger: An SNL Digital Short, Weekend Update: Forte Sings, Two A-Holes at a Travel Agency, How to Order Sushi Like a CEO, Vincent Price St. Patrick's Day.