While detouring around a road construction site, Will and Sonny are trapped by a landslide on a wilderness road, along with six other people: a runaway and her boyfriend, an alcoholic trumpeter and his estranged med-student son, and a man and his wife towing their RV.
After delivering a load to a San Diego cannery, Sonny gets a case of hams for his lady friend, but when she opens one, it is full of military ammunition. Then Will and Sonny go undercover to help find the rest of the stolen munitions.
Sonny and Will pick up a load from a Baltimore furniture factory whose owner has refused to pay a local thug "protection" money. The bomb intended for the factory ticks hidden in the trailer while Will tries to get Sonny to a dentist to fix his aching tooth.
Sonny's comment published in a trucker's magazine about truckers being "the toughest men in America" draws the ire of the US Marines, and results in a challenge to complete one week of Marine basic training at Camp Lejeune, North Carolina.
Sonny and Will pick up a carnival elephant in North Carolina to deliver in Sarasota, Florida. First, she gets loose on a country road, then Sonny finds a drunken stowaway in the trailer, then the rig is stolen . . . and Sonny's day goes downhill from there.
Sonny's impounded truck is bought by competing trucker team Moose and Benjy, leaving Will and Sonny with their ramshackle rig. A bet is struck that whichever truck can reach Raleigh and claim a letter mailed to general delivery wins both trucks. And the race is on . . .
Sonny and Will are hauling a load of apples out of Hendersonville when they come upon a bus that has a flat tire as a result of a gunshot. They and the passengers end up at an abandoned farmhouse, surrounded by gunmen who are after money that was stolen from a bank.
While Will goes to the bank in Asheville to cash a check, Sonny delivers a load to a North Carolina minimum security prison farm, and an inmate stowaway forces Sonny to take him to his girlfriend so they can get married.
Will and Sonny almost have a collision with Laura on a North Carolina mountain road after her farm truck has a brake failure. As Will finds himself attracted to her, Sonny finds himself suspicious of her motives, and of her hauling business.