Will and Sonny encounter Joe Shannon in Oregon after he crashes his truck trying to pass on a narrow road. After they take him, unconscious, to a hospital, the doctor informs them he is terminally ill, and they decide to make his last days enjoyable.
Will is taking a shortcut through the country when he spots fresh skid marks leading off the road to a bullet-riddled car. He and Sonny soon learn why the car is there: a modern-day Bonnie & Clyde . . . plus one.
Will, Sonny, and fellow trucker Ike run afoul of a small-town police officer and his speed trap, and they get involved in a series of "touch" football games that turn out rougher, and with higher stakes, than expected.
Will and Sonny pull a load of fresh eggs (and a trailer with a broken refrigerator) into Las Vegas, where Will meets two friends from back east: Rita, who is now a card dealer, and her ex-husband Chuck, a former stunt driver.
While in a cafe in Las Vegas, Sonny moans to Will about how depressing it is to spend Christmas on the road. So they head for Phoenix for dinner with Sonny's uncle, but end up with Sonny's ex-wife instead.
While detouring around a road construction site, Will and Sonny are trapped by a landslide on a wilderness road, along with six other people: a runaway and her boyfriend, an alcoholic trumpeter and his estranged med-student son, and a man and his wife towing their RV.
After delivering a load to a San Diego cannery, Sonny gets a case of hams for his lady friend, but when she opens one, it is full of military ammunition. Then Will and Sonny go undercover to help find the rest of the stolen munitions.