Barnaby's cousin, a cop from Chicago comes and calls him, he tells Barnaby he has a lead on the man who killed his partner, whom he's been looking for. But after talking to him, some men grab him and kill him. Barnaby's informed of his death. He then calls his son, J.R. who comes and demands to know what is being done to find who killed his father. Barnaby thinks he has a lead but proceed cautiously. But J.R. is impatient and goes on his own.
A man supplying secrets to an investigative reporter is murdered in the desert by the hired henchman of a crooked land developer. Barnaby is hired to investigate to get to the bottom of it, but not before another murder is committed.
A grieving widow asks Barnaby to look into the death of her charter pilot husband who died on a run. During the investigation Barnaby and J. R. discover a family operated money smuggling ring with a black sheep son stealing from them.
Barnaby and J.R. investigate a scuba diving death that seems unlikely to have happened the way it was reported. What they discover is more death and over $1,000,000 in jade art objects at the bottom of the ocean.
Barnaby, J.R., and Betty investigate a 10 year old kidnapping case after a man identifying himself as Scorpio calls a family offering to return his long lost daughter in exchange for a $250,000 ransom.
Barnaby suspects foul play following the accidental deaths of a judge and a doctor, who both received alleged phone calls just prior to their demise from a dead woman whom they both helped put into a mental institution years before.
In order to clear an innocent man Barnaby races against time to find an escaped convict who's testimony can set him free. Also trying to find the same convict is a bounty hunter with a reputation for bringing his quarry in dead.
Barnaby helps reunite a mother with her daughter on the day the daughter is released from prison. Then they ask him to find the daughters little boy who on the run with the ex-boyfriend, and he also happens to be involved in arms dealing.
A worried wife hires Barnaby to find out what has happened to her missing husband. In the course of their investigation Barnaby and J.R. believe that he was involved in a series of heists with his old college buddies, and that he may be dead.
While investigating the intentional death of a nun's biological sister who was on life support, Barnaby uncovers a prostitution ring in which the deceased was a part of. The leading suspect is Sister Terry, but Barnaby doesn't buy it.
While Betty is spending time with a group of friends tragedy strikes as one of the ladies is shot and killed during an alleged break-in. The leading suspect is the estranged husband of the victim, but Barnaby and J.R. dig up evidence (and other possible murders) that indicates it's one of the other friends.
A grieving daughter refuses to believe that her mother committed suicide and hires Barnaby to investigate. Together, Barnaby and J.R. unearth evidence that leads them to believe her death was linked to the estate of a recently deceased man who was worth millions.
One of Barnaby's friends, a small town sheriff, catches his beautiful wife cheating on him and murders two men who are illicitly involved with her. In order to try to get away with the killings he makes it look like the work of another killer who's on the loose,
Barnaby and J.R. try to protect a man who is on the run from gangsters who want to kill him before he can testify against them. But a femme fatal gets close to unsuspecting J.R. in order to find him first.
Barnaby, J.R. and Betty help a friend who was robbed by three men for a second time and raped by the ringleader of the group because she disobeyed him by going to the police after the first robbery. While investigating they discover that she is not the only one being terrorized by the same group.
Barnaby and J.R. investigate the death of a college professor that initially looked like a suicide, But as the truth begins to surface they discover he was really a terrorist turned government informant.
Barnaby and J.R. are concerned for Betty's safety after she receives threats from The Valentine Killer. Their investigations gives them several suspects, but after they catch the real Valentine Killer the threats continue.
The Starshine Sisters, a pair of singing sisters that Barnaby help put in prison a few months ago have escaped and are back to their larcenous ways. Now calling themselves The Dreammakers, Barnaby and J.R. are tracking them down again, but this time it's to save their lives.
The chief of security for an armored car delivery service asks Barnaby to investigate an attempted robbery at the company's headquarters because it looks like somebody inside the company may have helped with the robbery.
A young girl from a wealthy family runs away with a man saddled with gambling debts and she soon realizes that he is only after her fathers money. After witnessing a shooting he was involved in, she goes into hiding only to find more danger. Barnaby and J. R. race against time to find her before any harm can come to her.