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Followed by 

What's Up Doc (1978)

References 

Seven Chances (1925)
Battleship Potemkin (1925)
In chase scene where they ride the bike down the steps is a reference to the "Odessa Steps" sequence of Battleship Potemkin where a baby carriage careens down the steps
Bringing Up Baby (1938)
A scene nearly identical to the one where Susan rips the back center seam of David's coat where Judy does the same to Howard's coat.
A Wild Hare (1940)
title is a famous quote from this cartoon
Casablanca (1942)
The Caine Mutiny (1954)
Judge Maxwell brings out the steel balls, a la Cmdr. Queeg
Bullitt (1968)
The beginning of the chase scene is clear homage to the beginning of the iconic chase scene in Bullitt, complete with hubcaps flying off the cars.

Referenced in 

Evil Come Evil Go (1972)
Grauman's Chinese Theatre marquee approx 12 minutes into the movie
M*A*S*H: What's Up, Doc? (1978)
title reference
Time After Time (1979)
When H. G. Wells gets in the cab, the cab driver asks him "What's Up, Doc?" before racing perilously up and down San Franciscos's hills, alluding to this comedy that is also set in San Francisco and features a wild chase through the streets of San Francisco
A.D.A.M. (1988)
Mystery Science Theater 3000: Mighty Jack (1991)
Tom: "It's like 'What's Up, Doc?' all of a sudden."
Mystery Science Theater 3000: Master Ninja I (1992)
Crow: "They're just trying to keep away from the set of 'What's Up, Doc?'"
The Simpsons: Grampa vs. Sexual Inadequacy (1994)
The car chase in San Francisco is a reference to "What's Up, Doc?"
Outbreak (1995)
Family Matters: What's Up Doc? (1995)
title reference
Ellen: What's Up, Ex-Doc? (1995)
title reference
Stealing Sinatra (2003)
mentioned in connection with Ryan O'Neal
Who Wants to Be a Millionaire: Episode #7.140 (2009)
Subject of a $100 question
By Bogdanovich (2011)
mentioned in discussion of Bogdaovich's filmography

Features 

Air Force (1943)

Featured in 

A Night of Comic Relief 2 (1989)
Clip shown as part of The Barry Awards
100 Years of Comedy (1997)
Clips shown.
AFI's 100 Years... 100 Laughs: America's Funniest Movies (2000)
This film is #61 on the list.

Spoofs 

Love Story (1970)

Spoofed in 

Butt's Up, Doc (1992)
title parody

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