A thirty-year veteran beat cop and longtime friend of Stone's is shot during an attempted robbery. Stone sets off with a vendetta to get the gunman, blurring the line between professional and personal.
A businessman who flew in from Los Angeles (the time it takes to fly from L.A. to S.F. is the source of the title) for a convention meets a woman at the convention center and agrees to join her on her houseboat in nearby Sausalito. They get into an argument and he winds up striking her on the head and fleeing. The woman's boyfriend gets home, gets into an argument with her and again bashes her on the head, killing her. The businessman is the prime suspect in the murder because he was seen arriving at and then fleeing the crime scene.
Stone is sidelined with a broken ankle, so Keller teams up with hot-headed Inspector Jim Martin to track down a young Mexican suspected of murder. But Martin's prejudice against Mexicans threatens the investigation's success.
A city official is murdered in a botched mugging by a gang of three sophisticated criminals unaware of his high profile. The mayor, convinced it was a political assassination, orders Stone and Keller to crack the case.
Two young women are found murdered in a swinging singles apartment complex. As Stone and Keller investigate, they uncover multiple suspects with a motive to murder the two gold-digging, teasing "takers."
An ex-con college professor takes a bullet to the shoulder when a hit-man murders a blackmailer. But the professor refuses to have the bullet removed, and the hit-man is hot on his trail to recover the incriminating bullet.
Stone oversteps his authority when he entrusts to a traditional Greek patriarch his ex-con son just released from San Quentin. When the son is implicated in a suspicious fire, Stone and Keller's investigation uncovers ugly family secrets.