While off duty, Officer's Webster and Gillis are taken hostage by two men headed to Mexico in search of an unorthodox medical treatment for one of the men. After they escape the men, the officer's must trek through the desert to survive.
While on a night patrol Officer Gillis's partner is shot and killed. Then after notifying his estranged wife, she grabs his gun and shoots herself. The series of traumatic events leave him with plenty of doubt about his future as a cop.
Officers Danko and Webster must find an escaped convict infected with spiral meningitis before he spreads the disease to the general population. But they must also find his ex-wife because he is bent on killing her.