A famed psychic reads Maude's fortune and alerts her to some surprising events that will occur in the near future, one of them being that she will marry for a fifth time. Maude begins to worry about this possibility when the psychic's other predictions start coming true. Ultimately, Maude decides the best thing to do is to remarry Walter; however, he throws a fit when she suggests a double ring ceremony.
Maude and the gang come together to perform in a telethon that Maude has organized. However, when she fails to come up with a celebrity to appear in the telethon she is left organizing a telethon without a cause, when the charity for which Maude has put in a lot of work withdraws at the last moment. As the minutes wind down, she must come up with a cause or face being taken off the air.
When Maude recruits Vivian into women's liberation, Arthur is not pleased that Vivian is ignoring her "household duties," and when she tries to stand up for herself, Arthur refuses to listen, putting their marriage in a delicate position.
When Walter's business is in $12,000 debt and is facing bankruptcy, Maude suggests that she mortgage the house to get the funds, but a stubborn Walter won't let her, so she does anyway and ask Arthur to say the money came from him.
When Walter suddenly becomes passionate about religion and drags Maude to church services. Maude is less than thrilled with attending and can hardly stay awake. She becomes even more irate when she learns the reason for Walter's sudden conversion.
When Vivian and Arthur get into a sudden romantic mood which leads to Arthur inviting Vivian away on a romantic weekend to a cabin, Maude becomes unsure of her marriage with Walter. Trying to put the spark back in her marriage, Maude plans a romantic weekend but the situation turns out to be less than ideal.
Maude is a bundle of nerves with her mother's upcoming visit to meet Walter for the first time. Her insecurities come out when her mother arrives, just as Walter's first tv commercials hit the air and aren't as respectable as Maude hoped.
When Maude becomes overwhelmed with grief about Walter moving out into his new apartment, she changes her mind about breaking up and wants to get back together until she gets an eyeful of his new swinging singles apartment.
It is finally election day, and Maude is happy that her marriage is back on track and that her and Walter have reconciled. However, she's nervous that she may not win the election, especially when she appears on a television talk show and voices her liberal views toward premarital sex. Suddenly Maude realizes she may lose the election.
When Vivian and Arthur go out of town on a vacation, Vivian leaves her dog, Chuck in Maude's care. However, when Chuck unexpectedly passes away, Maude must break the news to Vivian but fears Vivian will blame her for Chuck's death.
When Maude has a session with a psychiatrist, she pours out all her innermost feelings, revealing her anxieties ranging from her feelings for her dead father, her resentment towards her mother and her fear of turning 50.
While accompanying Arthur on a trip to Pittsburgh to attend a medical convention, Walter poses as a doctor as a joke at the conference, but he is called for a real emergency when a handyman begins to have a heart attack in the hotel room.
Maude receives a letter from her ex-husband Albert, who believes he's on death's doorstep, and he arrives on Maude's doorstep with a final request of her. Meanwhile, Founders Day has Walter advertising in the local newspaper and gearing up for a big sale.
With Christmas on the way, Walter has his annual office Christmas party at the house. But he's worried that Maude's feminist friend, Stephanie, who goes out of her way to preach to everyone on women's rights, will put a damper on the festivities. Maude must step in and find the middle ground between standing up for women and free spirited frivolity of some of the party-goers.