This would be Laurie Bird's (as the girl/hitchhiker) film debut. She would only star in two more films including Cockfighter (1974) and Annie Hall (1977) before taking her own life in New York in 1979.
Floyd Mutrux, wrote much of the screenplay, but lost credit in a Writers Guild arbitration hearing due to the fact he was not a member of the Guild. Director Monte Hellman appeared in Mutrux's film The Christian Licorice Store (1971) the same year this film was made.
Dennis Wilson's watch used to time the race is a Rolex Daytona.
Three 1955 Chevrolets were used as the street racer in the film; both vehicles were built by Richard Ruth. One of the cars used in the film, with the twin carburetors, was driven by Harrison Ford in American Graffiti (1973), and the car that was seen at the gas station in the film--the 210 coupe, aka the #2 vehicle--was recently located in Canada, intact and untouched. The #3 car had a full rollcage installed and was to be used in a rollover scene that was not filmed. It was later used in the rollover scene in "American Graffiti".
According to the director’s commentary on the first DVD release, the reason the movie took so long to release on DVD was Jim Morrison. Two Lane Blacktop's sound track has scenes in the movie where Doors music is playing in the background. Monte Hellman and the producers had trouble initially securing permission from Morrison's estate to release the film with its original content of Doors music on to the medium of DVD. For obvious reasons, such DVD permission was not part of the original agreement with the Doors in 1972. Eventually, the studio got permission to use the Doors music again and the DVD was released.