The original ending was supposed to link Divine to the Charles Manson murders, but when it was discovered that the Manson family was responsible, the ending was changed to what it is in the final film. The original ending would have fed the publicity gag that Divine was responsible for Sharon Tate's murder.
The re-mastered Criterion version of Multiple Maniacs has had some songs replaced/substituted. The Elvis Presley songs "Jailhouse Rock" and "Just Because" have been taken out and replaced by similar pieces by George S. Clinton, as has the music on the opening credits.
John Waters said, "I made this film, which glorified violence, at the peak of the hippie love generation. But hippies liked it. Part of its success was to offend my target audience in a humorous way. Of course, now that sounds much more calculated than I was."
The trailer for the 2016 reissue featured the slogan "Filmed in Baltimore, where life is cheap-er," parodying Snuff (1975)'s tagline, "A film that could only be made in South America, where life is CHEAP!"