Locke is slightly hurt after a dynamite bomb goes off in the front yard of Dr. Sellers. Soon after, Sellers is occupied by a long time girl patient that seemingly goes crazy during an examination, and her father has a raging mistrust of him because of his age, blaming him for her condition.
In a remote farmhouse, a woman tends for her chronically ill, bedridden husband. Though Sellers sees the man living many more years with proper care, he dies very soon afterward. Locke performs an autopsy, and it's revealed his oxygen tank was replaced by inert gas.
A young Indian girl is pregnant, and soon to have her baby, however her husband wants to have it in hospital, but she would prefer the care of her tribe's medicine man, with his magic spells. Locke is bitten by a snake, with only the old shaman to help.
During hunting season,some of the deer hunters are being hunted down themselves, by a demented man with a tranquilizer dart gun. He ties the unconscious men to car hoods like deer carcasses. when Officer Palmer tries to set a trap, but it backfires and Locke takes action.
At a surprise fortieth birthday party for a local farmer, he starts punching out his friends, and later tells his wife he detests her because she's aging. It looks like a serious case of midlife crisis, but Locke determines he's affected by agricultural chemicals.
An unconscious man is found in one of the rides at an itinerant fun fair, and Locke diagnoses him as suffering from Typhus. Swiftly, the town of Dixon Mills is quarantined, leading to hardships for the angry and frightened residents. The disease's carrier has fled, and a desperate search ensues.
The town is in an uproar over the Quarantine, and police are still on the trail of a fugitive believed to be the Typhus carrier, but it's revealed he's running from a petty crime warrant. After Palmer becomes ill, he is shocked to find that the real carrier is the girl he's fallen in love with.
Driving along, a girl is hijacked at gunpoint by a deranged woman escapee obsessed with her face, scarred from a childhood accident. She forces the girl up to the crumbling balcony of a condemned old building, threatening a murder suicide if anyone gets near, yet Locke must try to talk her down.
On a dangerous mountain road deep in the woods, a distracted minister in a passenger car and a volatile chemical truck driven by a man arguing with his daughter, collide. Locke, Sellers and Palmer are soon on the wreck scene and find the trucker pinned inside as the truck may explode. The land's owner complicates things as he tries to stop their help.
An ex-con returns to Dixon Mills from his prison sentence which he served for the murder of his fiancée's father. She sees that as a tragic accident and still wants him enough to have a home with him at her family farm. He doesn't want her to know he has an inoperable degenerative eye condition, so he tries to convince her he's tired of her.
An old black man and a white boy living on the fringe scrounge an auto wreck yard for things to paint,yet he becomes the target of an assassin.The boy is encouraged to keep silent, and it's revealed the old man has a huge amount of possible counterfeit cash.
After only a few hours sleep, Locke must help Sellers with a houseful of patients, which include a lot of kids and a sad, lonely, dying old man. The most dramatic moment is when an injured girl, a murder suspect is brought in by Palmer, who threatens the life of Nurse Wynn with a stolen scalpel.
One of Doctor Locke's old patients back in the big city insists-even at the cost of his own health, that Locke and only Locke can do his diagnosis. So he leaves Dixon Mills to do it. Everyone worries he may decide to stay, while Sellers alone treats a mysteriously ill family at his surgery.
Careening off the road because of sabotaged brakes, a car crashes in a chemical warehouse. Locke and special fire rescue units try to extract a woman pinned in the wreck before explosive gases ignite, as her wheelchair-bound husband insists his business partner had to be responsible.
A girl with a degenerative disease walks with great pain trying to conceal her problem from an itinerant French ski bum she's fallen for. Sellers insists she must let him go or risk irreparable damage to her legs, and delay will prevent her admission to college as well.
A girl suffering from serious internal disease is reluctant to be treated, and the reason is soon apparent to the doctors- her husband has a bizarre obsession with physical perfection, and he lashes out, threatening them and rumormongering among the townsfolk.
A tough, ex-con and son of another convict is given a rehabilitation job- assisting Locke on the police ambulance. His old gang sees this position as an opportunity for cover in a get away out of a big heist they're planning. Feeling unappreciated, he agrees to help, dragging Locke into it.
A gravely ill foreign dictator is in town for some important diplomatic talks, along with his overbearing security detail. Locke wants to put him in hospital, but he won't leave a hotel where he feels safe, until a plot to assassinate him there almost succeeds.
Diner operators testify against a sadistic protection racket operator, only to have the case thrown out and they live in fear. Locke tries to help by buying the place, but the thug is interested in silencing further witnesses, including his own girlfriend.
After a cargo ship docks in the harbor,a diamond smuggling crewman's body is found and it's loaded with Cholera. Locke and the police force must race against time to locate and quarantine all his shipmates, including his killer, lest they spread an epidemic through the city.
After a bulldozer errantly knocks down a wall at a demo project, the father of the demolition team is rushed to the hospital while his son, Niko (Chakiris), finds $200,000 in the debris. After some debate, Niko agrees to turn the money over to police. The only trouble is the money is from a nearby robbery, in which $300,000 was stolen. The culprits want the missing loot.
Insurance agent Ben Grover stumbles onto a lucrative scam his bosses are using to steal from the company. Before he acts on it, an assassin is used to take him out, but they manage to only kill his wife instead. Grover then turns the tables seeking a deadly revenge.
No-account son-in-law of a wealthy drug dealer steals a car one day with a valuable shipment and his naive wife. They crash, and he must escape the hospital with the shipment in a suitcase, his father-in-law and the mob's wrath, as Dr. Locke tries to intervene.
A second rate, hot-headed lounge singer is injured when his girlfriend is abducted, but nobody believes it all isn't part of a cheap publicity stunt. Desperate, he begs his wealthy, but very much estranged father for the ransom money but gets turned down.
Gans is released from prison for securities theft and immediately collapses, drawing Dr. Locke to the scene. Kramer, an insurance investigator, is keeping close watch on Gans as the securities were never recovered. In addition Kramer used to date Jill Gans, his daughter.
During a theft of hospital supplies a shooting occurs and Dr. Locke arrives at the scene to treat the victims. He sees Lynn, a nurse who is also a former girlfriend. She appears to be part of organized robbery ring of the medical institutions.
Charley is part of a loan shark operation but hasn't been turning in his client's payments. When several of them are severely beaten Dr. Locke is called in and he starts to add things up. Charley's daughter Ruth and her expensive tastes may be the problem.
Luddy runs a half-way house for fellow ex-cons trying to make it back in society. Mistreated in the past by police, he's reluctant to help them even when they reveal that some of the residents are active criminals responsible for an old man's murder.
Dr. Simon Locke is called to a prominent citizen's house after a dead man is discovered. Police determine the man recently escaped from prison and his accomplice Frey is likely nearby and a murderer. Simon is instrumental in solving the case.
Several nurses are killed and one disappears leading Dr. Locke to zero in on a charismatic young doctor. The hospital administrator John Warren defends him, eventually drawing attention to himself. Simon must evaluate the evidence to save a young woman's life.
An ex-cop has become an alcoholic derelict. When one of his drinking friends is violently kidnapped by thugs in an ambulance from a local hospital, he convinces Simon to go under cover there to find out why. He finds a murderous insurance scam run by some corrupt doctors.
A second rate lounge singer playing second rate lounges wants desperately for his agent to book him in more important venues in the United States, but he never gets one. When the agent is found murdered in his dressing room, it looks like his spaced out drug addict girl friend did it, but she can't remember anything.
Policewoman Molly Sims increasingly cuts corners, including giving suspects the benefit of the doubt. Dr.Locke tries to convince her that it won't end well and Lenny, a hoodlum, intends to make her regret the break she gave him.
Andy Carrigan, a student from Ireland, is warned to stop looking for his father who disappeared ten years earlier. Dr. Locke becoming involved after treating Andy's injured hand. John Carrigan makes contact with his son but needs to keep his distance because he is involved in human trafficking.