John Astin appeared in three separate episodes of Night Gallery (1969). During each episode, his character was killed, and during two episodes, his character found himself in Hell. Also directed three episodes of the show.
Two segments, and possibly a third, were directed by a young Steven Spielberg. According to the book, "Rod Serling's Night Gallery: An After Hours Tour", Spielberg was scheduled to direct the 1971 vignette "A Matter of Semantics" starring Cesar Romero. Those involved with the production are unclear in their memory as to whether Spielberg actually directed the piece, which was ultimately credited to Jack Laird. At least one actor involved in the 2-minute mini-episode recalls a director who more closely fits Spielberg's description than Laird's. Beginning with the second season, and despite Rod Serling's objections, the producers began to insert brief 1-3 minute "blackout comedy" sketches in between main segments of some episodes, usually when an episode was running short. The merits of these brief vignettes remain controversial among Night Gallery (1969) fans to this day.
One year before the debut of the TV series Kung Fu (1972), David Carradine and Radames Pera, who each played the "Kung Fu" character of Kwai Chang Caine at different ages throughout that series, appeared in the same episode of "Night Gallery", though in different segments. Carradine appeared in "Phantom Farmhouse" (episode 2.16) and Pera appeared in "Silent Snow, Secret Snow" (episode 2.17).
Episodes from the hour long The Sixth Sense (1972), starring Gary Collins, were edited down into half-hours, and added to the Night Gallery syndication package. Studios find it easier to sell programs in syndication when they have more episodes in the package, as local stations know audiences are more likely to grow tired of a program is the same episodes are repeated over and over again within a short period of time. Adding the edited Sixth Sense programs made syndicating the program easier.
The syndication version of the series took individual segments from the original hour long program and worked them into half-hour episodes. This sometimes meant editing out footage from original episodes that ran longer than a half hour, or adding footage to those that originally were shorter than a half hour.
Rod Serling had originally conceived of a show like Night Gallery when he was still working on The Twilight Zone. He had originally wanted to change the stories to be shown during the final season from fantasy to horror (the genre he preferred), but CBS adamantly refused to agree to it. Unfortunately for Serling, on Night Gallery he did not have the same kind of control over the program like he did on Twilight Zone, as he was just the host and occasional story contributor). Serling frequently clashed with the show's producer of the quality of stories shown on the program.