| Peter Falk | ... | Lt. Columbo | |
| Gene Barry | ... | Dr. Ray Flemming | |
| Katherine Justice | ... | Joan Hudson | |
| William Windom | ... | Burt Gordon | |
| Nina Foch | ... | Carol Flemming | |
| Virginia Gregg | ... | Miss Petrie | |
| Andrea King | ... | Cynthia Gordon | |
| Susanne Benton | ... | The Blonde | |
| Ena Hartman | ... | Nurse | |
| Sherry Boucher | ... | Air Hostess | |
| Anthony James | ... | Tommy | |
| rest of cast listed alphabetically: | |||
| Jim Creech | ... | Policeman in Hospital (uncredited) | |
| Clark Howat | ... | Doctor (uncredited) | |
| Mark Russell | ... | Policeman (uncredited) | |
| Don Stewart | ... | Airline Ticket Man (uncredited) | |
| Tom Williams | ... | Laundry Delivery Man (uncredited) | |
Directed by | |||
| Richard Irving | |||
Writing credits | ||
| Richard Levinson | (teleplay) & | |
| William Link | (teleplay) | |
| Richard Levinson | (play) & | |
| William Link | (play) | |
Produced by | |||
| Jerrold Freedman | .... | associate producer | |
| Richard Irving | .... | producer | |
Original Music by | |||
| Dave Grusin | |||
Cinematography by | |||
| Ray Rennahan | (director of photography) | ||
Film Editing by | |||
| Richard G. Wray | |||
Art Direction by | |||
| Russell Kimball | |||
Set Decoration by | |||
| John McCarthy Jr. | (as John McCarthy) | ||
| James Redd | (as James S. Redd) | ||
Makeup Department | |||
| Larry Germain | .... | hair stylist | |
| Bud Westmore | .... | makeup artist | |
Production Management | |||
| Edward K. Dodds | .... | unit manager | |
Second Unit Director or Assistant Director | |||
| George Bisk | .... | assistant director | |
Sound Department | |||
| James T. Porter | .... | sound | |
Costume and Wardrobe Department | |||
| Burton Miller | .... | costumes | |
Editorial Department | |||
| Richard Belding | .... | editorial supervisor | |
| Robert Brower | .... | color coordinator | |
Music Department | |||
| Stanley Wilson | .... | musical supervisor | |
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| Fracture | So Sweet, So Dead | Giornata nera per l'ariete | Dial M for Murder | I Confess |
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| Full cast and crew | Company credits | External reviews |
| News articles | IMDb Crime section | IMDb USA section |
This surely was a fantastic way to give birth to in my opinion the greatest television detective ever. Terrificly charming Peter Falk (who stills looks so bloody young in this one) shines in the role of Columbo right from the beginning. Personally I think the best episodes was yet to come, after all quite a bunch of these films was made. But there's nothing wrong with "Prescription: Murder". It is unquestionably an excellent start that could instantly hook anyone to watch the whole series. I mean who wouldn't love this man, his mannerisms, cigars, talks about his wife and other clever trademarks. The whole series is a delightful and unforgettable masterpiece of TV history. I have to give 9 out of 10 already to the first one.