The team goes to see Eve's friend perform at a local bar where she is performing in a trio. After a delay in starting time, the two male trio members who are brothers announce to the audience that the friend will not be able to perform that night. When she can't get in touch with her friend and the body of a young murder victim that may be related to the band is discovered, Eve becomes involved with one of the brothers.
Ironside and his team have to escort a Czechoslovakian refuge to Mexico where she is to be traded for an American scientist. But it appears that someone has blown their cover and that a third party is now involved.
Ironside and crew assist an ex-convict whose son has been kidnapped by a militant group so the ex-convict will supply them with explosives from the construction company at which the man has been employed.
Ed and Eve go south of the border to interview Lonnie Burnett, someone Eve helped clear of a murder charge in the US but now faces a similar charge in a foreign country. A muckraking reporter also shows up and complicates their situation.
Ironside, who has invested money in a controversial stage show, brings his team to a rehearsal when it's discovered one of its performers has died mysteriously from a drug overdose. With such a large cast there are any number of suspects.
Mark, who has been up for three nights on an extended stakeout, accidentally hits an elderly woman. Mark befriends her and gradually uncovers her secret past. Meanwhile Ed works on a separate jewel heist case.
An underground terrorist group breaks a member out of jail. The son of a prominent lawyer appears to have a connection to the group but Ironside isn't sure if he is a willing participant in their schemes.
Ironside investigates a purse-snatching, but not just the usual petty crime: the victim is the widow of the former head of the Police Commission, and the purse contained a little cash . . . and $200,000 in jewelry.
After a parole officer is shot at Ironside finds the list of possible suspects is quite long. A drug pusher may be responsible since he is especially hard on them after his sister was confined to an institution after a bad drug experience.
After one of those delivered dies from a reaction to a drug, Ironside investigates a ring that uses a phony cab to deliver men to a sham party at motels where the men are drugged and their credit cards stolen
Ironside is trying to take down an illegal gambling operation. But when there's a raid the people in charge somehow find out and clean it out. Ironside suspects that someone in the department is tipping them off. And he has to deal with Fran Belding, a policewoman who is determined to take them down because she thinks that someone in the operation killed her father a cop. And Ironside is feeling weak, so he sees his doctor who tells him that he has a condition which needs to be treated and will require a long recuperation so he puts it off.
Ironside and his team receive a surprise visit from his Korean foster daughter who came to San Francisco to marry the young man she loves. But no one knows that the groom-to-be is in debt to a pair of local loan sharks.
After an AWOL soldier saves Brown from a gun battle and gives first aid for Brown's leg wound, Ironside's crew helps exonerate the soldier for a murder for which he has been framed by a drug ring operating inside the military.
After a killer of a policeman receives a hung jury, the policeman's partner is setup by the head of the killer's loan shark ring to have the policeman's partner look like he has killed the policeman's killer in cold blood.
An old classmate of Ed's is on the run after assaulting another man. Ed's investigation into the case leads him to reconnect with old classmates, including an old girlfriend who may know where he's hiding.