On Ironside's advice, produce-company owner Dora Copeland refuses a loan from a man with ties to organized crime. The man retaliates by trying to frame Dora's son, a struggling lawyer, for attempted rape of a young woman.
Ed becomes close to a new movie star who may have been given the key to a safe-deposit box by a criminal moments before he was killed. Ironside searches for the dead man's cohorts before they can harm the girl.
The chief's vacation is disrupted when his host, a World War II buddy, goes missing. Ironside allows himself to be kidnapped as well so he can find his ailing friend and foil a plot to steal two million dollars' worth of gold.
Eve is kidnapped along with her friend, who is being held for $50,000 by a group of hippies. When the friend's husband takes back the money, Ironside wonders who masterminded the plot. Eve, meanwhile, looks for a way to escape.
With his assistants away, the chief receives a phone call telling him to expect a deadly visitor within sixty minutes. Ironside spends the remaining time improvising self defense without weapons - and trying to identify the caller.
A Native American parolee for whom Ironside arranged a job in a jewelry store is suspected of burglarizing it. He was last seen with his cousin, who had just dropped out of school. Ironside and Mark search for both men.
When the crown prince of an Eastern European country slips out of his consulate, Eve stays with him. Ed is assigned to keep an eye on them, but someone gave his car two flat tires. Ironside follows to make sure the prince is safe.
As a favor to the dog's owner, Commissioner Randall asks Ironside to locate a missing hound. When the team investigates, they find two dognappers are capturing numerous canines and demanding huge rewards.
Dayton, who was convicted of causing the death of Ed's fiancée seven years ago, is paroled. Although Tom personally asks him for forgiveness, Sergeant Brown broods over the possibility that Dayton will strike again.
A key witness is gunned down by a young man trying to evade the military draft. The shooter's pregnant, widowed girlfriend may be the only clue to his whereabouts as Ironside strives to catch him before he flees to Canada.
Leland McIntyre asks Ironside to find out who is trying to kill him. Eve finds several students connected with the eight-year-old murder case the judge is reenacting in Mark's law class. Ed sits in so he can be a bodyguard for McIntyre.
The investment manager for the police pension fund is charged with murdering his secretary. The man says he did it, but Ironside is puzzled by gaps in his confession and by large amounts of money the secretary had collected.
While in Quebec for a police convention, Mark is nearly killed by French separatists. Ironside's involvement in the case is complicated when the man arrested as the bomber is the son of a former lover.
When it becomes clear a police raid was tipped off, the evidence begins to show that Ironside may have been responsible. Ed joins the internal investigation that will either clear - or convict - Ironside.
Pablo Esteban, a young faith healer from a small Mexican village, lays hands upon the willing in big cities across 1970 America. Pablo lays hands upon a friend of Ironside who convalesced with him and was similarly disabled in San Francisco. When she regains her ability to walk, Ironside, Ed and Mark attempt to investigate whether a miracle or human avarice is responsible.
One evening, Chief Ironside and Mark Sanger visit a precinct where the Chief worked as a young officer. Initially, the precinct Captain, played by 70's NFL hero, Roman Gabriel, greets the Chief formally, as if he thinks Ironside is there to meddle. In contrast, Ironside's old partner, played by veteran actor, Jack Albertson, is happy to see Ironside. Suddenly, there is a city-wide blackout; now, the young Captain is relieved to have Ironside on site and even provides him an office. There is a rush to organize and institute emergency protocol but the Chief remains ...