Ironside's Aunt Victoria suspects foul play when one of her card-playing friends vanishes. Despite her nephew's admonitions, Victoria and her bridge partners shadow their missing friend's husband, who insists his wife left him.
A friend of Mark is found drunk and bending over an assault victim. Even though his night-school law teacher and Ironside lend assistance, Mark becomes frustrated with the legal process as he tries to help his friend gain an acquittal.
A one-time movie star is missing, and the people who know her can't say where she went. Ironside and his assistants encounter forgery, extortion, and attempted murder in their efforts to find the young actress.
Eve becomes romantically involved with a writer who seems to be living beyond his means. Ironside traces a theft ring to a telephone answering service used by Eve's boyfriend, who becomes the prime suspect in a series of home burglaries.
Ed Brown runs into officer Ray Leonard, an old friend moonlighting as a cab driver and finds a package of drugs in his taxi. Returning to find the previous fare, Leonard shoots the man three times, killing him. Suspected of drug trafficking, both policemen are promptly suspended pending an investigation. Ironside and his team also investigate to clear Ed.
Stakeholders in a pharmaceutical company try to gain approval for a dangerous anti-rejection medicine just before a lucrative merger. Ironside thinks the owner knows who has been frightening her with accidents and strange voices.
Ex-cop Mel Grayson kills his wife and carries out an elaborate plan to mislead police and establish an alibi for himself. Mrs. Grayson appears to have been killed while he was dining with his old friend Ironside. Chief Ironside suspects Grayson immediately, explaining to Ed that her murder while her husband was with him is just too convenient.
Ed's friend, a major-league baseball player, receives a series of threatening letters. He then claims an object was thrown at him in the outfield during a game. Ironside must find the culprit before the attacks become more deadly.
A young woman is found dead from internal bleeding after an abortion. Using previous cases and clues provided by Ironside, Eve goes undercover to track down an abortionist who has had several other patients die.
Mark's Aunt Ruby loses her life savings to a distinguished-looking con artist. In an effort to recover the money, Ironside sets up Ed and Eve as a wealthy couple in a resort so the thief can be caught trying another scam.
Ironside gets an unexpected call from Barbara Richards, the woman he once helped reclaim her life after she had lost her memory. Her daughter has been kidnapped and he agrees to help despite the fact he's still in love with her.
Ed is captured by a convict who claims small-town sheriff Harvey Poole let him escape so he could be killed. Eve and Mark deal with some brutal deputies to help Ironside see if any prisoners died while in Poole's custody.
In charge of security for Americans at a diplomatic conference, Ironside is asked by his stubborn Chinese counterpart to find out why the leader of the latter's delegation is dying. The chief suspects airborne poison, but who released it?
Ironside goes into action when a Hebrew school is vandalized. The rabbi, an acquaintance of the chief, is most concerned about a missing Torah. The sacred scroll, it turns out, is being held for ransom.