The chief of staff for a millionaire's citizen vigilance group is found dead in his wrecked car. Ironside looks into a theory that the murderer was an organization insider trying to set up the victim as a martyr.
Ironside knows a man Mark ran errands for as a child is a convicted robber who may be involved in the murder of a gangland racketeer. Mark, however, defies a warning to stay away from his old acquaintance.
Ed helps two patrol officers arrest a restaurant owner who vows revenge upon his release. Both of the policemen are murdered a few days later. Convinced that the restaurateur is the killer, Ed pursues him against Ironside's orders.
A detective working part-time as a bank guard shoots a patrolman who catches him robbing the bank. After a week in hiding and unable to leave the city, he meets with Ironside to turn himself in, but kidnaps him instead and forces Mark to drive them north out of the city. His wife and son are waiting at a cabin in Tahoe where a chartered plane is coming to fly the family to Mexico.
Eve shoots and kills one of the two men involved in a jewelry store robbery. Stunned when she finds out he was only seventeen years old and everyone that knew him says he was a fine young man, she questions her commitment to police work. After she tells Ironside she is quitting, he convinces her to finish the case and finds a way to help her regain her confidence.
In an informal talk at a local college, Ironside says all criminal plots are flawed. An anonymous student challenges that statement by wounding several people - including Eve - with long-range rifle shots.
The plane Ironside was about to board is bombed, and a baby is left in his van! Ironside takes the infant boy home to wait for his mother and her ex-husband, the only people from the plane's passenger list who are unaccounted for.
Ironside's former colleague is found guilty of fatally shooting his wife and her lover. When the judge, district attorney, and witnesses from the trial are threatened or killed by bombs, Ironside believes two separate forces are at work.
A charming thief arrives in San Francisco with murderous plans to steal a priceless jewel collection. Ironside's assignment: to make sure the jewelry is transported into and out of a museum without incident.
Just before his spinal surgery, Ironside asks the public to help find the person who stole drugs from the hospital and killed a guard. The chief does not know that the same man has been planning for Ironside to die on the operating table.
On vacation in the mountains, Ironside tries to find a former hunting buddy. The chief is then kidnapped by a wealthy rancher and his son, who have been plotting to steal the land belonging to Ironside's old friend.
A former detective, now living on the streets, alerts Ironside about the death of another homeless man. He joins Ironside on the case and discovers the death is connected to someone passing bogus checks.
Numerous bits of evidence indicate Ironside's former girlfriend shot and killed her husband, but the chief wants all of the facts before an arrest is made. Ironside also thinks the "victim" might still be alive.
Officer Whitfield is shot and critically wounded in a pawn-shop holdup. As Ironside works to solve the crime, he recalls how he first met Eve several years earlier while he was still walking and she was a rich society girl.
A millionaire is murdered, his chauffeur is severely beaten, and a smoke bomb is shot into Ironside's office - all in the presence of a talking mynah bird. Ironside and his team try to find out what the bird knows.
Ironside writes a letter of recommendation for a pool hustler who plans to attend college. When the young man changes his mind and agrees to a high-stakes game against a legendary billiards champion, the chief wants to know why.