After one of those delivered dies from a reaction to a drug, Ironside investigates a ring that uses a phony cab to deliver men to a sham party at motels where the men are drugged and their credit cards stolen
Ironside is trying to take down an illegal gambling operation. But when there's a raid the people in charge somehow find out and clean it out. Ironside suspects that someone in the department is tipping them off. And he has to deal with Fran Belding, a policewoman who is determined to take them down because she thinks that someone in the operation killed her father a cop. And Ironside is feeling weak, so he sees his doctor who tells him that he has a condition which needs to be treated and will require a long recuperation so he puts it off.
Ironside and his team receive a surprise visit from his Korean foster daughter who came to San Francisco to marry the young man she loves. But no one knows that the groom-to-be is in debt to a pair of local loan sharks.
After an AWOL soldier saves Brown from a gun battle and gives first aid for Brown's leg wound, Ironside's crew helps exonerate the soldier for a murder for which he has been framed by a drug ring operating inside the military.
After a killer of a policeman receives a hung jury, the policeman's partner is setup by the head of the killer's loan shark ring to have the policeman's partner look like he has killed the policeman's killer in cold blood.
An old classmate of Ed's is on the run after assaulting another man. Ed's investigation into the case leads him to reconnect with old classmates, including an old girlfriend who may know where he's hiding.
One by one members of a parole board are being murdered. On the assumption that the remaining ones will be next, Ironside goes undercover and pretends to be an artist, whom he finds to be an eccentric and irascible man.
A highly impressionable 9-year-old-girl (Jodie Foster) thinks she has cast a spell which caused a mean man to fall and suffer a fatal skull fracture. She is even more upset when a huge, bald, man with severe mental problems (Lee Paul) says he shoved the victim to the ground because 'he made me mad'. Ironside and his team work to prove that neither the girl or the bald man killed the victim - and he finds that someone came upon the victim after he fell and finished him off with a blow from a blunt instrument.
Ironside is on the trail of mysterious, illusive high level heroin dealer while trying to discover the reasons for an apparent urgent, clandestine visit from an old friend and discovers that there might be a link between two investigations.