Mark's Aunt Ruby loses her life savings to a distinguished-looking con artist. In an effort to recover the money, Ironside sets up Ed and Eve as a wealthy couple in a resort so the thief can be caught trying another scam.
Ironside gets an unexpected call from Barbara Richards, the woman he once helped reclaim her life after she had lost her memory. Her daughter has been kidnapped and he agrees to help despite the fact he's still in love with her.
Ed is captured by a convict who claims small-town sheriff Harvey Poole let him escape so he could be killed. Eve and Mark deal with some brutal deputies to help Ironside see if any prisoners died while in Poole's custody.
In charge of security for Americans at a diplomatic conference, Ironside is asked by his stubborn Chinese counterpart to find out why the leader of the latter's delegation is dying. The chief suspects airborne poison, but who released it?
Ironside goes into action when a Hebrew school is vandalized. The rabbi, an acquaintance of the chief, is most concerned about a missing Torah. The sacred scroll, it turns out, is being held for ransom.
On Ironside's advice, produce-company owner Dora Copeland refuses a loan from a man with ties to organized crime. The man retaliates by trying to frame Dora's son, a struggling lawyer, for attempted rape of a young woman.
Ed becomes close to a new movie star who may have been given the key to a safe-deposit box by a criminal moments before he was killed. Ironside searches for the dead man's cohorts before they can harm the girl.
The chief's vacation is disrupted when his host, a World War II buddy, goes missing. Ironside allows himself to be kidnapped as well so he can find his ailing friend and foil a plot to steal two million dollars' worth of gold.
Eve is kidnapped along with her friend, who is being held for $50,000 by a group of hippies. When the friend's husband takes back the money, Ironside wonders who masterminded the plot. Eve, meanwhile, looks for a way to escape.
With his assistants away, the chief receives a phone call telling him to expect a deadly visitor within sixty minutes. Ironside spends the remaining time improvising self defense without weapons - and trying to identify the caller.
A Native American parolee for whom Ironside arranged a job in a jewelry store is suspected of burglarizing it. He was last seen with his cousin, who had just dropped out of school. Ironside and Mark search for both men.
When the crown prince of an Eastern European country slips out of his consulate, Eve stays with him. Ed is assigned to keep an eye on them, but someone gave his car two flat tires. Ironside follows to make sure the prince is safe.
As a favor to the dog's owner, Commissioner Randall asks Ironside to locate a missing hound. When the team investigates, they find two dognappers are capturing numerous canines and demanding huge rewards.
Dayton, who was convicted of causing the death of Ed's fiancée seven years ago, is paroled. Although Tom personally asks him for forgiveness, Sergeant Brown broods over the possibility that Dayton will strike again.