A charming thief arrives in San Francisco with murderous plans to steal a priceless jewel collection. Ironside's assignment: to make sure the jewelry is transported into and out of a museum without incident.
Just before his spinal surgery, Ironside asks the public to help find the person who stole drugs from the hospital and killed a guard. The chief does not know that the same man has been planning for Ironside to die on the operating table.
On vacation in the mountains, Ironside tries to find a former hunting buddy. The chief is then kidnapped by a wealthy rancher and his son, who have been plotting to steal the land belonging to Ironside's old friend.
A former detective, now living on the streets, alerts Ironside about the death of another homeless man. He joins Ironside on the case and discovers the death is connected to someone passing bogus checks.
Numerous bits of evidence indicate Ironside's former girlfriend shot and killed her husband, but the chief wants all of the facts before an arrest is made. Ironside also thinks the "victim" might still be alive.
Officer Whitfield is shot and critically wounded in a pawn-shop holdup. As Ironside works to solve the crime, he recalls how he first met Eve several years earlier while he was still walking and she was a rich society girl.
A millionaire is murdered, his chauffeur is severely beaten, and a smoke bomb is shot into Ironside's office - all in the presence of a talking mynah bird. Ironside and his team try to find out what the bird knows.
Ironside writes a letter of recommendation for a pool hustler who plans to attend college. When the young man changes his mind and agrees to a high-stakes game against a legendary billiards champion, the chief wants to know why.
Ironside's Aunt Victoria suspects foul play when one of her card-playing friends vanishes. Despite her nephew's admonitions, Victoria and her bridge partners shadow their missing friend's husband, who insists his wife left him.
A friend of Mark is found drunk and bending over an assault victim. Even though his night-school law teacher and Ironside lend assistance, Mark becomes frustrated with the legal process as he tries to help his friend gain an acquittal.
A one-time movie star is missing, and the people who know her can't say where she went. Ironside and his assistants encounter forgery, extortion, and attempted murder in their efforts to find the young actress.
Eve becomes romantically involved with a writer who seems to be living beyond his means. Ironside traces a theft ring to a telephone answering service used by Eve's boyfriend, who becomes the prime suspect in a series of home burglaries.
Ed Brown runs into officer Ray Leonard, an old friend moonlighting as a cab driver and finds a package of drugs in his taxi. Returning to find the previous fare, Leonard shoots the man three times, killing him. Suspected of drug trafficking, both policemen are promptly suspended pending an investigation. Ironside and his team also investigate to clear Ed.
Stakeholders in a pharmaceutical company try to gain approval for a dangerous anti-rejection medicine just before a lucrative merger. Ironside thinks the owner knows who has been frightening her with accidents and strange voices.
Ex-cop Mel Grayson kills his wife and carries out an elaborate plan to mislead police and establish an alibi for himself. Mrs. Grayson appears to have been killed while he was dining with his old friend Ironside. Chief Ironside suspects Grayson immediately, explaining to Ed that her murder while her husband was with him is just too convenient.
Ed's friend, a major-league baseball player, receives a series of threatening letters. He then claims an object was thrown at him in the outfield during a game. Ironside must find the culprit before the attacks become more deadly.
A young woman is found dead from internal bleeding after an abortion. Using previous cases and clues provided by Ironside, Eve goes undercover to track down an abortionist who has had several other patients die.