A security guard is implicated in the theft of $175,000 from a horse-racing track. Even after the suspect dies in a car crash, Ironside is sure he left clues about where to find the money - and who ordered him to steal it.
Warren Stuart, number two man in a big crime syndicate in San Francisco, wants to leave the criminal world and start a new life. He has tried to contact Ironside several times, to reveal important information about the criminal organization. When he is killed by a sniper, Ironside is quite sure that John Trask, the number one man, ordered the assassination. Ironside is since a long time clear about who the leaders of the crime syndicate are. The problem is that he cannot find any evidence against them. Now he sees a chance to catch the leaders, by arranging a trap for...
A policeman that Ironside has known for some years is on an investigation and gets shot and killed. The evidence seems to look like the policeman is crooked, Ironside is determined to prove that this is not the case.
Ironside and Eve are held hostage at police headquarters by escaping criminals Carter and Baines. The criminals give Ironside a way to survive, He must become a "criminal" and come up with a plan for them to escape.
Ironside investigates an accidental electrocution that Ed thinks is a murder and finds a pattern of murder and greed over a Swiss bank account in which a group of WWII veterans have stored loot from a bank heist during the war.
Mark's boyhood pal, now a pro football star, refuses Ironside's request to start a sports program for inner-city youths. The gridiron hero then discovers his recently-paroled younger brother has been working for illegal bookmakers.
An old friend of Ironside's, now a P.I., is murdered. The only "witness" is a woman who happens to be blind. Ironside takes a calculated risk that the killer doesn't realize this and sets a trap to catch him when he comes back to kill her.
A hard-working carpenter is about to be extradited to the state of New York and executed for a murder he was convicted of committing 19 years earlier. Ironside races against time to prove the man's innocence.
In Las Vegas in police business, Ed meets a pretty singer, takes her to dinner and later to her home, where she abruptly leaves and Ed is assaulted. Ironside investigates the connection between Ed's assailants and the mysterious young lady.
The chief of staff for a millionaire's citizen vigilance group is found dead in his wrecked car. Ironside looks into a theory that the murderer was an organization insider trying to set up the victim as a martyr.
Ironside knows a man Mark ran errands for as a child is a convicted robber who may be involved in the murder of a gangland racketeer. Mark, however, defies a warning to stay away from his old acquaintance.
Ed helps two patrol officers arrest a restaurant owner who vows revenge upon his release. Both of the policemen are murdered a few days later. Convinced that the restaurateur is the killer, Ed pursues him against Ironside's orders.
A detective working part-time as a bank guard shoots a patrolman who catches him robbing the bank. After a week in hiding and unable to leave the city, he meets with Ironside to turn himself in, but kidnaps him instead and forces Mark to drive them north out of the city. His wife and son are waiting at a cabin in Tahoe where a chartered plane is coming to fly the family to Mexico.
Eve shoots and kills one of the two men involved in a jewelry store robbery. Stunned when she finds out he was only seventeen years old and everyone that knew him says he was a fine young man, she questions her commitment to police work. After she tells Ironside she is quitting, he convinces her to finish the case and finds a way to help her regain her confidence.
In an informal talk at a local college, Ironside says all criminal plots are flawed. An anonymous student challenges that statement by wounding several people - including Eve - with long-range rifle shots.
The plane Ironside was about to board is bombed, and a baby is left in his van! Ironside takes the infant boy home to wait for his mother and her ex-husband, the only people from the plane's passenger list who are unaccounted for.
Ironside's former colleague is found guilty of fatally shooting his wife and her lover. When the judge, district attorney, and witnesses from the trial are threatened or killed by bombs, Ironside believes two separate forces are at work.