Mysterious events start occurring on the ranch putting the ranch hands in danger. But who is behind it? Some of the hands quit in fear forcing the Cannons to find who is behind the incidents and why they are occurring.
Victoria is injured when a prisoner, a doctor being held for murder by a marshal, tries to escape. Big John is left with no choice but to have the prisoner operate on her. He has to go against the marshal who believes Victoria will die.
Buck and Manolito decide to take some time off to "work" at their own ranch. They can't agree on what needs to be done while Comancheros are waiting to steal the horses they round up and kill them for stealing their horses earlier.
With Sam gone Big John is driving the men crazy trying to run the ranch alone. They nominate Joe to take over as foreman to which Big John agrees. However, problems surface over one of the new hands Joe hires who he knows has a bad past.
Buck knowingly hires a gunman Johnny Rondo and his son to work at the ranch. Johnny has given up his guns and is taking his son to California. However, three men catch up with them and want revenge for the death of their young brother.
Victoria's father visits and tries to take advantage of the custom Mi Casa, Su Casa which irritates the Cannons. It also creates trouble with the Apaches when he accidentally gives away Apache cattle putting the ranch in danger.
A young Army officer who is an old friend of the Cannons is sent to arrest a neighbor for desertion during the civil war. However, when Blue tries to help him, the incident literally blows up when the officer uses excessive force.
Blue is a temporary deputy for a weekend during which Well Fargo is held up. He arrests Buck and Manolito for disorderly conduct and they unwittingly help him capture the robbers in a weekend of tricks and paybacks between them.
Buck and Victoria are held up as they travel to her dad's hacienda with $1500. Victoria is taken hostage by the robbers and forced to work as the hostess in a bar. Buck heads after her but is captured so they plot their own escape.
Big John is suffering from exhaustion and the cure is time away from the ranch. He and Victoria leave on a delayed honeymoon in San Francisco but things at the ranch don't go so well with Buck, Blue, and Manolito managing it alone.
Buck runs into his Captain from the war in the Army as a Sergeant leading a patrol and wagon of gold to Yuma. They need a scout. He takes on the role only to find his friend and men are stealing the gold and crossing into Mexico.
Blue's style of drawing draws teasing from the men and Big John's concern he is ignoring his work. Victoria submits his work back east where it is published. When he receives an offer to go back east to study, Big John is hurt.
Buck and Manolito go with Victoria to protect her on the way to another ranch to help deliver a baby. However, an attack by Apaches lead to Victoria being taken hostage by an Apache followed by three bank robbers who threaten to kill her.
Both the High Chaparral and Montoya's hacienda are threatened by a man who wants revenge for having his hacienda sold by the government to Montoya. Adding to the problem, he was the childhood sweetheart of Victoria, who he wants back.
Against the advice of the others Buck goes to the town of Spokes for the Fourth of July. Instead of celebrating he saves an old hide hunter from the father of the man he killed, who he caught cheating at cards, and from the townspeople.
Manolito returns to the High Chaparral with Montoya's stallion after paying a breeding fee for Big John. On the way back the stallion and his money are stolen. His father persuades Manolito he should make an effort to recover the horse.
Big John proposes the ranchers work together to drive their own herds to Wichita instead of Texas to increase their profit. However, it appears the Apaches may be causing problems with a young brave Big John released helping them.
Victoria along with Sam and Pedro come under attack by Apaches along with a baby and his grandfather. They are fifty miles from the ranch with the Apaches staying on their trail with horses that are wore out and no food for the baby.
Tulsa Red arrives at the ranch asking Big John for $5000. When he refuses, Tulsa threatens to kill Buck the next time he comes to Tucson. Big John decides to pay but when Buck learns about it, he retrieves the money in spite of the threat.
When Big John decides to sell supplies to Maximillian revolutionaries in Mexico, he creates a lot of animosity. The community, the hands, Buck, Manolito and even his wife Victoria fight him. Sam and Wind, however, stick with him.
On a trip to sell cattle Manolito recovers the money stolen from a stage, but is charged with stealing it himself. After a friend has him released from jail, he is framed for the murder of the town founder and in deeper trouble with the law.
Two young Apaches clash over what the tribe should do as their Chief dies. One wants to kill the white men while the other who has been chosen as the new Chief wants peace with the whites. Big John has to decide if he can trust the offer.
On the way to a wild time at Fiesta in Mexico, Buck runs into the sport of boy fighting in a cantina. He rescues the losing boy from the fight and his owner but finds the boy and himself in danger from the men he took the boy from.
Dan Casement returns on the hunt for three men who burned his ranch and killed his grandson. He rescues Buck and then returns to the High Chaparral to return a crucifix Victoria had given to his grandson Joey while Sam decides to help him.
A young white man held as a slave by the Apache is chased by them to the ranch house where the Cannons protect him. However, Wind and the hands don't trust him although he says he hates the Apache so they accept him with reservations.
After finding his wanted poster, Buck tells Victoria and Manolito about his life after the war as a wanted man. Big John was a lawman who tracked him down helping him against his Civil War pals who held up a bank for which Buck was wanted.