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Fantastic Voyage (1966) Poster

Trivia

The scenes of crewmembers swimming outside the sub were shot on dry soundstages with the actors suspended from wires. There was some additional hazard involved because, to avoid reflections from the metal, the wires were washed in acid to roughen them, which made them more likely to break. To create the impression of swimming in a resisting medium, the scenes were shot at 50% greater speed than normal, then played back at normal speed.
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When filming the scene where the other crew members remove attacking antibodies from Ms. Peterson for the first time, director Richard Fleischer allowed the actors to grab what they pleased. Gentlemen all, they specifically avoided removing them from Raquel Welch's breasts, with an end result that the director described as a "Las Vegas showgirl" effect. Fleischer pointed this out to the cast members - and on the second try, the actors all reached for her breasts. Finally the director realized that he would have to choreograph who removed what from where, and the result is seen in the final cut.
Medical schools, at least as late as the 1980s, would show clips from this film to illustrate various concepts in human anatomy, physiology, and especially immunology.
The time spent in the movie of the crew once they were miniaturized is in real time, taking up almost exactly one hour of the movie.
Isaac Asimov was approached to write the novel from the script. He perused the script and declared it to be full of plot holes. Receiving permission to write the book the way he wanted, delays in filming and the speed at which he wrote saw the book appear before the film.
During filming, one of the two 3 inch "Proteus" models used in the miniaturization sequence was left by an open window and was subsequently carried off by a crow.
A now defunct thrill ride at Disney's Epcot Center, called Body Wars, was largely inspired by this film, even though it is not a Disney film. The director, Richard Fleischer, however, also directed Disney's first science fiction film, 20,000 Leagues Under the Sea (1954).
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Voyage to the Bottom of the Sea (1964) reportedly 'borrowed' props from the elaborate sets of this film for an episode in which a diving bell is swallowed by a huge whale.
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In his book, special effects man L.B. Abbott writes about making use of a giant champagne glass built for another movie to fill with water and use for the whirlpool sequence when the ship is sucked through a tear in the artery. Althougth he doesn't mention the movie's name, it is most likely the film _What a Way to Go (1964)_ which had a sequence of Shirley MacLaine lounging in a giant champagne glass.
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The plot of this movie has partly been anticipated by (or been plagiarized from) the first season episode I Dream of Jeannie: The Moving Finger (1965). In that episode, Captain Nelson works as technical consultant for a studio making a movie, in which an American astronaut, shrunken to the size of a pinhead, is injected into the bloodstream of a Soviet astronaut, works his way to the brain and retrieves information vital to the defense of the country.
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The sound effects played over the opening credits were created for the computer in Desk Set (1957).
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The end credits title card reads, "Opening credits prologue: The makers of this film are indebted to the many doctors, technicians and research scientists, whose knowledge and insight helped guide this production."
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The miniature brain sets were used to represent the interior of the alien spacecraft in Lost in Space: The Derelict (1965).
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As a college student, director Richard Fleischer was a pre-med student for a time.
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