When asked about this movie Burt Reynolds replied "It looked every inch of its $70,000 budget. The heavy was played by the hotel bell hop, because he had a deep voice. The prop man series up once and used live ammo. I fought a cobra that hadn't been milked of its poison. And near the end I did a fight scene in a river that was contaminated with pollutants. Perhaps it wouldn't have mattered even if I'd had a spleen to purify my blood. As it was, the toxins got in to my system and went to town."
After filming a fight scene in a river that was contaminated with pollutants near the end of shooting, Burt Reynolds went to Alabama to participate in a March with Dr. Martin Luther King , Jr. one day he woke up in hospital, with lymph glands the size of softballs. At first it was assumed he had Hodgkin's disease. Finally it was revealed his mystery illness was schistosomiasis - snail eggs in the bloodstram. By luck the cure was only discovered two years earlier.
The third season of the show Archer, the episode "The Man From Jupiter" features and co-stars Burt Reynolds. In this episode, Sterling Archer tells him "Operation C.I.A." is the reason he becomes a secret agent.