The Ghost and Mr. Chicken was an extended reworking of an episode of The Andy Griffith Show: The Haunted House (1963), (7 Oct. 1963), that was particularly successful for the show and attracted a large audience.
Besides Don Knotts, there are a number of actors from the Andy Griffith Show in this movie, some playing characters very similar to the characters they did in the Andy Griffith Show. For example, Hal Smith plays the town drunk in both productions, and Dorthy Neumann plays Smith's wife in both productions. Also, "Griffith" show veterans, such as Burt Mustin and Hope Summers are featured in this movie. This was Knott's first film after leaving the Andy Griffith Show.
The outside street scenes in the opening credits to "The Ghost and Mr Chicken" were filmed at Universal Studios Back lot. The mansion shown is the Harvey (1950) House, now seen in Desperate Housewives (2004).
One of the few American films shot in the Technicolor Corporation's Techniscope wide screen process. The wide screen effect was achieved by essentially splitting the usual film frame horizontally into two smaller frames with a greater width to height ratio. It was inexpensive, but yielded a grainy image, which probably explains why it was seldom used in Hollywood.
Contrary to some belief, the exterior of the Simmons house was not the same one built for Alfred Hitchcock's Psycho (1960). The Simmons house is a different facade located on what used to be named Colonial Street on Universal's back lot, and has been used in several other shows.