Gung Ho captures Horsey, mistaking him for Fearless Fly. Muggy-Do, working as a bellboy, makes a dishonest buck off a movie-star guest. Professor Weirdo tries to prevent his Aunt Hagatha from seeing Milton.
Goo Fee steals Fearless Fly's matchbox, falsely believing the super-insect to be inside. Spider Webb hires a Mexican bandit to stop Flukey Luke. Prof. Weirdo sells Milton to a gangster running a protection racket.
Fearless Fly must stop Prof. Weirdo from turning small animals into monsters. Stuffy Durma tries to sneak Ash Can Annie into the mansion. Prof. Weirdo and Prof. Fruitcake engage in a deadly game of tit-for-tat.