Daniel and Mingo are taken prisoner by a Spanish officer named de Vaca while on a trip out West. De Vaca mistakes Daniel for someone named Gabriel. After he discovers his error, he forces Daniel to track Gabriel by holding Mingo prisoner.
Daniel and Mingo travel to Florida and meet a traveling magician named Cameron. His illusions impress the Seminole's chief who considers him a god. Cameron then tries to use the same tricks to win over other tribes-hoping to rule them all.
In Salem, Boone is mistaken for one of two army deserters bounty hunter Simon Harman is searching for. Harman intends to return both men to Fort Savage until he learns of Daniel's true identity. He can get much more money for Boone if he turns him over to the British in Quebec.
Col. Barr, recently court-martialed in Virginia, comes to Boonesborough to start over. When Mingo finds an Indian baby with smallpox, which threatens everyone with an epidemic, Barr uses it as an excuse to seize power while Daniel is away.
While Daniel's in Lancaster, Pennsylvania to have a rifle made, an unscrupulous tavern owner tries to obtain his quipu. Given to Daniel by a Shawnee chief, the quipu guarantees him safe passage through Shawnee territory, which the man needs so he can transport, to New Orleans, gold he plans to steal.
As the execution of Edward Eliot is carried out under the supervision of Colonel Calloway, his brother Matthew Eliot, watching from the stockade where he awaits the same fate, vows revenge. After escaping jail, Eliot, and his confederates, kidnaps Jemima and Israel to force Daniel to bring Calloway to him.
In order to stop the British from taking Fort Cumberland, Governor Patrick Henry of Virginia recruits Daniel to lead a small group of men to blow up a bridge at Stover Station. In order to get there in three days they must travel through dangerous Tuscarora territory with the help of Tuscarora Chief Catahecassa.
Cassady was supposed to build a new road in the wilderness around Shawnee land. But when he decides there isn't enough time before winter to build the longer route, he decides to go straight through Shawnee land and into a possible war.
Daniel is taking a boatload of furs to New Orleans when he is jumped and pushed off his boat. When he comes to, he heads to New Orleans to track down the thief. The plot thickens, however, involving a pretty woman, a fight in a hotel lobby, and a search for buried treasure.
William Blunt, an old friend of Boone's, steals a wagon carrying fifty rifles and powder, which he intends to sell to the Shawnee. Daniel, along with Mingo and Jericho, must find Blunt and recover the rifles before a deal with the chief is made.
A group of renegade scalp-hunters led by Rafe Todd robs Boone's cabin and heads upriver. When Daniel finds out, he goes after the men because Mingo and Israel are also upriver retrieving a cache of furs.
Daniel and Mingo find an old man and a small boy while fur trapping. The boy speaks no English and says one word,"Cibola". The old man believes the boy is named for-and knows the location of-the legendary lost city of gold.
It's the year 1775, and Daniel Boone is blazing his Wilderness Road through the Cumberland Gap in the Appalachian Mountains - from North Carolina and Tennessee into Kentucky. With Boone is a wagon train of settlers. On the way, he meets and befriends Mingo.
Cletus and Wilse Mott have been tracking a bear ever since it killed their pappy three years ago, but after it kills Wilse, Cletus' obsession becomes a mania. Daniel and Mingo decide the bear must be killed when it threatens Boonesborough, but Mott warns them off saying the bear is his. When Daniel kills the bear to save Mott's life, he turns on him.
Mingo hears of a British organized uprising of Indian tribes in western Kentucky. He fights the other chiefs in allowing this uprising to occur, because failure to either support the uprising or warn the settlers and Daniel of the danger is a betrayal he can not live with.
Boonesboro gives $100 to Otis Cobb for an errand, but he ends up spending it, under curious circumstances, on a slave, Goliath. The town wants Otis to work off the debt for fifty cents a day, but when a wrestler and his manager come to town seeking to fight for money, Goliath ends up fighting to pay off the debt.
Big Zack, a bear hunter, comes to Boonesborough to trade a prime grizzly pelt for supplies. Unbeknown to him, a band of Shawnee led by a man bent on avenging his brother's death at the hands of Zack is tracking him.
Daniel and Israel ride on a stagecoach that becomes hijacked. Daniel ends up going to fetch a ransom for something on the stage, while Israel and the stage driver wait with the highwaymen. Will Daniel return in time?
Daniel and Mingo are entrusted with an Indian princess and asked to escort her to her betrothed in order to unite the two tribes and avert war. The young princess does not want the arranged marriage and fights them every step of the way.
Daniel and the other settlers in Boonesborough will lose their land if they do not pay a new tax of one shilling per acre within two weeks. As Daniel is about to take the money to Williamsburg an old friend shows up offering to help.
Red Sky, a Shawnee brave, thinks he is invincible after Daniel gives him his rifle for saving Israel's life. When several white men kill some braves, Daniel wants them brought to trial but Red Sky is determined to mete out Shawnee justice, which could start a war.
Kanati Green is shot and killed in front of Mingo after telling him of Indians being driven from their own land and giving him the title to his land at Logan's Fort. The title has been transferred to his father, a stubborn man who will not be driven off the property. Before delivering the deed Mingo stops by Daniel's cabin for a make-over.
The government gives 1000 pounds of gunpowder to Boonesborough, and Daniel has to pick it up and bring it back by boat. There's only one man, Bill Sedley, that he wants to hire to help him with the boating, but Sedley is as un-trustworthy as he is tough.
A young boy, the future king of France, is kidnapped in New Orleans by agents of the new French republican government. Daniel is hired to guide them to a secret rendezvous point but soon realizes the boy is hiding a secret.
Count Alfonso De Borba is looking to curry favor from the British and offers to give them the Liberty Bell, which he has managed to capture. The British are interested but insist that he also deliver Daniel Boone with the Bell.