A woman accused of witchcraft and her small son flee from a mob and escape to Boonesborough. They are found in the wilderness and nursed back to health by Daniel and Rebecca, but when her husband arrives the hysteria begins again. It is up to Daniel to use courage and wisdom to stand down the charges of witchcraft and help this family of innocent strangers.
A British officer is kidnapped by a group of Shawnee Indians intent on revenge because of his involvement in a massacre. He escapes and Boone finds him and gets involved in reconciling enormous hatred on both sides.
Daniel and Mingo come across the massacre of a Cherokee camp. Mingo is outraged but Boone calms him enough to focus on seeking these men out and bringing them to justice before Cherokee warriors extract their revenge.
While out hunting, Daniel and Cincinnatus come upon Timothy the peddler just after he has scared off a group of Shawnee. In Boonesborough they learn he's looking for his daughter Becky, Daniel's wife, whom he abandoned when he walked out on her mother many years earlier in Ireland. Their reunion is not a happy one.
A French officer named Michelet conspires with the various Indian tribes to lay siege to Boonesborough. The Indians appear to have overwhelming numbers and the cutoff townspeople are desperately short on supplies.
Boone and the people of Boonesborough hole up in the fort using every means possible to fend off the attacking Indians while hoping that a promised British relief force will reach them before it's too late.
A man is found dead by a group of travelers, one of them hears a strange noise and believes it to be the Devil in the form of a black panther. Daniel and Mingo believe a far more mundane explanation is at hand, and investigate to prove their point.
Israel accidentally startles a passing peddler's horse and his goods are ruined. Daniel agrees to compensate him for his loss but matters are complicated when he steals a grieving Indian women's mourning doll.
Jericho and Sumah, the daughter of the Indian chief, want to marry. Daniel proposes a trial engagement. For a month Jericho will live with the Indians and Sumah will live with Boone's family and see if each can adapt to the other culture.
Boone returns from a solo expedition to find Boonesborough eerily empty. A corrupt British officer has kidnapped the settlers, including Boone's family, and forces them into unfriendly Chickesaw tribal lands with the intention of gaining personal control of the territory. He then captures Boone and demands that he sign away all rights to Boonesborough or watch his family and friends be turned over to the tribe. Boone manages to escape, but realizing he has no chance of freeing the captives on his own, he turns to a surprising source of help.
The annual footrace with the Creeks is looming, and everybody in town has big bets on Daniel to win the race against the Creeks' champion, Deerfoot. When Daniel hurts his foot, they fortunately find a good substitute, Jericho Jones, but he is very stubborn, feeling hurt that they never asked him before. Is he capable and willing to win, and pull the town's "fat out of the fire?" And, what are Stinch and Coll up to?
Daniel and Mingo encounter a strangely dressed Indian fighting of a hunting party. After rescuing him they begin to try and unravel who he was and where he came from. Mingo suspects he may be the sole survivor of a tribe wiped out 200 years ago by the Spaniards.
An athletic escaped slave commits a series of brazen, but non-lethal, thefts of furs from trappers in order to secure enough money to buy passage back to Africa. Daniel decides to set a trap and gets more than he bargained for when they cross paths. Upon finally subduing the determined rogue, Daniel finds that his real conflict is with the man the slave has been selling the stolen furs to - a treacherous nemesis he banished years earlier who is back for revenge.
Israel discovers an elderly Indian left to die by his tribe and nurses him back to health. Daniel and Mingo realize that Israel has interfered with a sacred tribal ritual, but when they try to mend the unintentional meddling, they stumble into a hidden conspiracy that may get them killed.
Boone is recruited by a representative of the Governor to capture and return John Benton, a rabble-rousing trouble-seeking ruffian due for an appointment with the hangman's noose. After snaring Benton from the midst of his nefarious companions with a rather unique ploy, Boone drives him on a trek through the wilderness to justice. He finds himself acquiring a grudging respect for the scoundrel along the way. Their path, however, is fraught with danger beyond Benton's wily attempts to escape, including wildlife, Shawnee, Benton's cohorts, and worst of all, treachery ...
Aaron Burr, ex-Vice President, comes to Boonesborough to enlist Daniel to guide him on a long and dangerous journey to the west, but is vague about his reasons for the trek. When Daniel turns him down due to his unease about Burr's secretive intentions, Jericho blindly jumps at the chance to take the offer and earn a hefty fee. After Burr and Jericho leave, Daniel discovers Burr's true mission, and he and Mingo set out to intercept them and save Jericho from his own naivety.
Highlander settlers begin building a settlement on land that belongs to the Cherokee, threatening the peace. Daniel tries to mediate but finds the Highlander's leader is unwilling to negotiate with "savages".
With Daniel and Jericho away and Choctaw chief Gabriel and his warriors on the warpath, a happy and peaceful Thanksgiving is in doubt. Then Rebecca's Irish father Timothy Patrick Bryan shows up and, in order not to disappoint his grandson Israel, who believes his yarns, invites the Indians to Thanksgiving dinner.
Captain Grant shows up at Boonesborough in the middle of the night, looking for Daniel, who is off on a trip with Rebecca. In a big hurry, Grant obtains a horse and starts after them. He catches up to Daniel, but is then immediately shot. He give Dan a letter from the President and directs Dan to take it to New Orleans to deliver it. The two men that shot Grant follow Daniel and Becky all the way, desperate to prevent the delivery of the letter.
Just before Christmas a blizzard drives everyone from their homes to the safety of Boonesborough. Tempers are as short as food when an Indian couple, about to have a baby at any time, show up seeking shelter.
Mingo finds a woman, who claims she is the sole survivor of an Indian massacre, wondering alone in the wilderness. Daniel, Mingo, and a Capt. Ives agree to escort her back to safety but they soon discover she has a hidden agenda.