A young Cherokee boy is shot and is near death. Daniel Boone must find out who shot the boy in order to head off the angry Cherokee tribe from retaliating against everyone, killing many innocent people.
Visiting New Orleans to sell the furs they've trapped, Daniel and Josh become mixed up with a beautiful French jewel thief who is attempting to double-cross the rest of her gang. The gullible Josh falls for the scheming woman's charms, which allows her to hide the stolen bauble inside his guitar.
The British commander of Fort Detroit will turn over the fort's defense plan if the Americans will reunite him with his wife. Daniel and Cully escort her back to him but Daniel doubts the Colonel's willingness to be a traitor.
Josh and Gabe are captured by a Spanish officer who tells them another Spanish officer is secretly building a base from which he intends to invade the U.S. He asks them to infiltrate the fort and steal his plans to prevent another war.
Daniel and his family find themselves being continually terrorized by an old man and his sons. The old man blames Boone for the death of his wife and for leaving him crippled, even though Daniel has no memory of ever meeting him.
While trading furs Daniel acquires an indentured servant who was born in prison and has never been free. Daniel intends to release him from service but the young man has trouble adjusting to his new life.
When a trapper is murdered Josh is fingered as the killer. Daniel encourages him to surrender with the idea that the real killers will be easier to catch once he is in custody. But will Josh be hanged before they're caught?
While transporting a box filled with gold for the Continental army, Daniel is beset upon by thieves. Complicating matters is that Israel is taken hostage as protection from Daniel while they lug the gold over the mountains.
A woman long thought dead is discovered by Daniel living with the Chickasaw. Daniel tells her her husband is still alive and that she should come back. She does, but her husband has trouble accepting her Indian son.
Daniel and Gabe become prisoners of the British after blowing up an important bridge. After escaping custody with another prisoner, they slowly work their way home through enemy territory. But they may be pawns in a larger plan.
Josh and Gabe are sent to Yorktown to intercept the arrival of Sir Peacham, an eccentric inventor, who is employed by the British but secretly sympathetic to the Americans. Josh and Gabe's mission is complicated by his daughter's intrigues.
Cincinnatus thinks he has found the fastest runner around and brings him to Boonesborough for a big race. His dream for success is complicated when another unknown runner enters the race and that the runners have a scheme of their own.
Just before he is due to be married, Mason encounters a man he believes is the same man who destroyed his family's home when he was a child. Daniel tries to show him revenge is not the answer, especially when based upon a boyhood memory.
Two goof-balls swipe another man's pelts and then trade them to a con man, who gives them a false land deed to all of the land of Boonesborough. Daniel's plan to set things right is complicated when a Marshall arrives to arrest him.
An Indian brave attends the school to learn about the white man's ways. The school kids want the teacher to teach them more about the Indians, but he will have nothing to do with "savages". The kids in return begin a protest movement.
While in New Orleans with Daniel, Josh 'inherits' two abandoned children from a poor widow. Unwilling to leave them to become orphans, he takes them with him back home only to find caring for two kids is a lot harder than he thought.
Two inept brothers stumble into the middle of an Indian religious ceremony. Desperate to save their lives, they promise to bring back a woman whose hair is like fire, a description that conveniently describes Rebecca Boone.