After escaping a police dragnet in Lincoln City, Nevada, Kimble comes upon Sister Veronica and her broken-down truck on a road in the desert hills. She convinces him to accompany her on her trip to Sacramento, despite his protests that he's heading in another direction.
A man helps Kimble escapes from a Sheriff and is wounded. As he nurses him, he discovers the man is tortured by a very guilty conscience in connection with a murder rap he was acquitted of months before.
Richard Kimble meets an old army buddy who saved his life during an explosion in the Korean War, and got badly disfigured in the process. Filled with bitterness, this ex army person plots to either disfigure Kimble, or kill him.
A dragnet traps Dr. Kimble to within a few city blocks while hides out in a house owned by two men. One of the men believes Kimble is innocent and the other does not, and wants to turn him over to the police.
Near Kansas City, Richard Kimble reads a want ad cryptically informing him about the murder of his wife Helen, with a message to phone Eleanor Burnett, the daughter of John Burnett, his defense attorney who is no longer alive. Ellie and her mother Ada had hired a private detective to help find the one-armed man and he believes he now has, but when Kimble arrives to a rendezvous with Ellie she informs him that the one-armed man they discovered had died in a fire. Kimble is devastated but checks the story himself and believes it to be true. However the private detective...
Kimble's aiding a stranded motorist lands the fugitive in a murderous love triangle. Town floozy Lucey's car stalled waiting for adulterous Lark Adams, who she claims didn't show for a rendezvous. Lark's body was already in a roadside ditch when Kimble and Lucey met. Kimble believes Lucey's innocent. So does a gallant Deputy who saw Kimble at Lucey's right after, but his Sheriff and the town's blue-bloods would love to pin the rap on loose Lucey, out of sympathy for Lark's abused blonde wife, Amy Adams.
The Cheyney's, bitter over Harold being hit by one of Pryor's trucks without receiving proper compensation, plans to kidnap Pryor for ransom but instead kidnaps Kimble working as Pryor's gardener thinking Kimble is Pryor.
When someone develops symptoms of the plague Kimble is forced into a difficult position: should he report it and risk getting caught or ensure his safety by leaving town and ignoring a potential epidemic.
When robbers shoot two policemen, Kimble's nearby, so he hides in orphanage's station wagon to get away from the dragnet. Two orphans he met beforehand promise they'll alibi him, but Sean Dubose, another state ward, plans to use Kimble in his own escape - fearing he'll be shipped to an Illinois juvenile prison soon. Sean's embittered from being abandoned by his alcoholic uncle, after Sean's parents' deaths. Kimble is torn between an immediate, but risky daylight escape, or helping the troublesome boy.
Kimble, on the run again, finds himself stranded on a broken down bus on a remote mountain road. The passengers discover Kimble's true identity and one of them, armed with a gun, is determined to turn him in to the police.
Kimble is photographed with a Congresswoman during her inspection of a military construction project. After they are trapped underground, Lt. Gerard arrives on the scene, confident that he has finally caught Kimble.
Kimble is riding with a man named Hanes who is driving back to his hometown. When Hanes starts a fight, the sheriff arrests them both, as he recognizes Kimble as a wanted man. A troubled youth named Tad plans to help Kimble escape.
A singer, who bears a strong resemblance to Kimble's dead wife, arrives at a club he works at and offends everyone with her boorish behavior. He eventually discovers her rudeness is due to a personal and tragic secret.