Near Kansas City, Richard Kimble reads a want ad cryptically informing him about the murder of his wife Helen, with a message to phone Eleanor Burnett, the daughter of John Burnett, his defense attorney who is no longer alive. Ellie and her mother Ada had hired a private detective to help find the one-armed man and he believes he now has, but when Kimble arrives to a rendezvous with Ellie she informs him that the one-armed man they discovered had died in a fire. Kimble is devastated but checks the story himself and believes it to be true. However the private detective...
Kimble's aiding a stranded motorist lands the fugitive in a murderous love triangle. Town floozy Lucey's car stalled waiting for adulterous Lark Adams, who she claims didn't show for a rendezvous. Lark's body was already in a roadside ditch when Kimble and Lucey met. Kimble believes Lucey's innocent. So does a gallant Deputy who saw Kimble at Lucey's right after, but his Sheriff and the town's blue-bloods would love to pin the rap on loose Lucey, out of sympathy for Lark's abused blonde wife, Amy Adams.
The Cheyney's, bitter over Harold being hit by one of Pryor's trucks without receiving proper compensation, plans to kidnap Pryor for ransom but instead kidnaps Kimble working as Pryor's gardener thinking Kimble is Pryor.
When someone develops symptoms of the plague Kimble is forced into a difficult position: should he report it and risk getting caught or ensure his safety by leaving town and ignoring a potential epidemic.
When robbers shoot two policemen, Kimble's nearby, so he hides in orphanage's station wagon to get away from the dragnet. Two orphans he met beforehand promise they'll alibi him, but Sean Dubose, another state ward, plans to use Kimble in his own escape - fearing he'll be shipped to an Illinois juvenile prison soon. Sean's embittered from being abandoned by his alcoholic uncle, after Sean's parents' deaths. Kimble is torn between an immediate, but risky daylight escape, or helping the troublesome boy.
Kimble, on the run again, finds himself stranded on a broken down bus on a remote mountain road. The passengers discover Kimble's true identity and one of them, armed with a gun, is determined to turn him in to the police.
Kimble is photographed with a Congresswoman during her inspection of a military construction project. After they are trapped underground, Lt. Gerard arrives on the scene, confident that he has finally caught Kimble.
Kimble is riding with a man named Hanes who is driving back to his hometown. When Hanes starts a fight, the sheriff arrests them both, as he recognizes Kimble as a wanted man. A troubled youth named Tad plans to help Kimble escape.
A singer, who bears a strong resemblance to Kimble's dead wife, arrives at a club he works at and offends everyone with her boorish behavior. He eventually discovers her rudeness is due to a personal and tragic secret.
A woman hires Kimble to be the caretaker of her brother who was disabled in a car accident. Her boyfriend wants her to run away with him along with her brother's insurance money. Kimble becomes the unwitting patsy in his scheme.
A young woman, desperate to be free of her mother's manipulating control, plans to marry a boy her mother doesn't approve of. Kimble tries to help but the girl's other suitor threatens to expose him if he interferes.
A police roadblock, including Lt. Gerard, causes Kimble to escape cross country into an area populated with moonshiners. With Gerard in hot pursuit, they're both caught, and Kimble must defend Gerard to keep him from being hanged.
A small town is on edge because two women have been murdered. Kimble is stopped by a group of vigilantes who suspect any stranger. He escapes and hides in an abandoned building where he is helped by a young naive woman.
Kimball hides in a home for the blind after his likeness appears on television. In the home resides former police chief Brady, blinded in the line of duty and who wishes to prove the incompetence of the current chief by nabbing Kimball.
After falling in with two other escaped fugitives Kimble has to accompany them when they force themselves into the home of a woman and her mother. He then has to figure a way out while also trying to protect the women.
The son of a rich landowner comes back home to take over the business after his father's accidental death. The son's return brings resentment from some of the workers who believe he's responsible for a young woman's death.
Not knowing the cops are close behind him, Kimble gets a job at Jungle Land, a small-town animal attraction that is in financial trouble. One of the Jungle Land partners hatches a plan to have Kimble captured on the premises for the publicity.