Dr. Kimble is working as a hired hand on a failing ranch while the local sheriff is looking for a recently escaped murderer. Meanwhile, back in Stafford, a national newspaper publisher offers a $10,000 reward for Kimble's capture.
While working for a small town veterinarian, Dr. Kimble comes across the sick baby of an unwed mother whose religious father doesn't believe in medicine. As Kimble secretly treats the baby, a jealous dismissed deputy discovers his true identity.
Kimble duels the man with one arm, Bill, in a warehouse loaded with explosives. In Kimble's latest job as a developer in a photo lab, he spotted a snapshot including Bill. The teenage camera bug who took the shot ekes out a living as a small-time blackmailer, as he waits for his big break as a photographer. The childless Kimble needs the young lens-man's help in tracking Bill, and feels a fatherly concern about the budding photojournalist's cynicism and morality.
While driving through vineyards, Dr. Kimble and two passengers are shot by a sniper killing one who was a union organizer. Kimble can identify the sniper but the police and powerful owners of the town winery conspire to keep him quiet.
While working as a bartender, Dr. Kimble sees the one-armed man in a live news broadcast. After arriving on the scene Kimble chases the man which causes a woman to be hit by a car. While treating her at a hospital, he discovers she has had a relationship with the one-armed man and might be able to tell Kimble where he is.
The police are looking for a young fugitive who was dating the daughter of a Hungarian family that Dr. Kimble is staying with. As the police stake out their residence, Dr. Kimble discovers her father is also running from a crime he was accused of.
Kimble's saves his boss' life, garnering the ranch owner's powerful protection but Kimble doesn't want his favors, because the owner's a hit-man gone legit. With Lt. Gerard closing in, the wealthy retired assassin sends the detective in the opposite direction from the fugitive, into a trap where Gerard will be taken off the hunt for good.
Police drag in Kimble when a co-worker robs the liquor store the fugitive's clerking in. Some police suspect Kimble's involved, but their chief knows he's not - because his alienated son is the stick-up man. To repair their relationship the desperate father needs to get his son off. Will he feed Kimble to his wolves to do so ?
While working as a deck hand on a charter boat, a company believes the skipper left the country after embezzling cash and securities. The police decide to use an agent as the boat's replacement skipper since the next passenger is the embezzler's wife who intends to meet up with him in Mexico. The police also decide to investigate the mysterious deckhand since he has no background.
While attending a baseball game, a woman Dr. Kimble is sitting next to is told that she has a phone call and is kidnapped. As Kimble is the only one who saw the kidnapper, her rich father coerces him into helping find his daughter.
Dr. Kimble meets with a fraternity brother who is now a professor of sleep research at a university and has seen the one-armed man working there. The professor has an elaborate plan to extract proof from the man that he killed Kimble's wife.
A deadly love triangle sucks in Kimble as fall guy for a murder. An ambitious lounge singer romances the fugitive hoping to force the hand of her married lover into divorcing his rich, disabled wife Norma for the duplicitous songbird. When that scheme fails, the young mistress convinces the reluctant husband to use convicted killer Richard Kimble - to permanently remove Norma from between the illicit couple and the wife's millions.
While waiting to leave a small town in Montana, Dr. Kimble is spotted by the authorities and arrested. He is cleared for having stolen a truck but the sheriff decides to jail him for having resisted arrest and suspects he's not who he says he is. While Kimble is held in jail, another prisoner determines his true identity.
An immigrant cigar maker's son is accosted by neighborhood bullies and calls the police to put a stop to the harassment. The only witness to the incident is Dr. Kimble whose face seems oddly familiar to the officers.
Kimble is blackmailed into slaving for a physician obsessed with curing a deadly strain of meningitis prevalent in a remote Mexican province. The fugitive put ashore in Mexico, after fleeing U.S. police, and swapping places with a departing sailor. The expatriate Dr. Howell will stop at nothing to wipe out his "tiny enemy," but Richard Kimble contests the ethics of Howell's fanatical methods, as a wily local police sergeant closes in on the convicted killer.
A diplomat's slip lands Kimble in the only place he can't be re-captured: a Washington, D.C. embassy. Dr. Kimble ministers to the ambassador from a newly democratized African nation, when the emissary is almost flattened by a D.C. cab. Everything looks cozy for the fugitive, who's in town to court an appeal specialist - especially bunking down the hall from the legation's man-eater secretary.
When the one-armed man Fred Johnson is arrested in LA for smashing up a bar, the news is flashed nationwide (courtesy of Lt. Gerard), and Richard Kimble learns of Johnson's arrest at a trucking firm in Tuscon. Gerard is waiting in the wings for Kimble's arrival, but unknown to Gerard also working at LAPD headquarters is court stenographer Jean Carlisle, who is close to the Kimble family because they helped her cope with her father's arrest for embezzlement. Upon learning of Gerard's presence, Jean calls Richard's sister Donna and learns that Richard is probably headed...
On the train back to Indiana, Kimble convinces Girard to give him one day to track down the one-armed man. Someone in Stafford arranged to have the one-armed man bailed out of jail. It turns out that man was a local war hero who witnessed the killing of Mrs. Kimble. That witness now wants to try to kill the one-armed man. Kimble tries to get to the one-armed man first, hoping to end the running once and for all.