A trio of soldiers are transporting a prisoner across Shiloh property when they learn after a run in with Trampas it appears the prisoner has scarlet fever. Elizabeth and Holly Grainger find the prisoner stranded and inadvertently help him escape. The Graingers are concerned with contracting scarlet fever while Trampas helps two of the soldiers who have their own internal feud recapture the prisoner. However, Trampas is plagued with flashbacks of his own history with scarlet fever.
An old friend of Trampas, Jed Matthews, is hired for his gun to come to Medicine Bow by rancher Tom Tallman to fight homesteaders blocking a pass used by the ranchers to take their cattle to market. Tallman has Jed go to work at Shiloh to spy on their plans as the ranchers have differing views on how to handle the problem. Trampas introduces Jed to the sister of a homesteader who falls for Jed forcing him to choose sides in the dispute.
While on a trip Trampas runs into a dog, Ulysses, who leads him to the ailing Joe Keller. Joe asks Trampas to locate his lost niece who is in the town where Trampas is to visit a girl he along with her family. However, Joe does not remember the name or a description of his niece other than the strawberry mark she has on one knee. Complications due to this task severely interrupt Trampas's attempts to see his friend especially when he is caught inspecting multiple knees in his hotel room by her and her family.
Warden Keane asks Clay Grainger to take three convicts as employees while on parole. He is trying to persuade the prison board that parole might rehabilitate some convicts with greater success. Unknown to Grainger a marshal has been assigned to work undercover at Shiloh to report on problems. When he exposes the men as convicts, it complicates the work environment and the three men have differing views on their future plans.
Elizabeth finds the outlaw Jim Dewey shot and about to die from blood loss. Her and Clay bring him back to Shiloh where everyone is gone except them and Holly due to a cattle drive. While they nurse Dewey back to health, the bounty hunter Ben Hicks arrives revealing the outlaw's identity and wanting to take him in preferably dead but they stop him. Elizabeth is persuaded by Jim he really has a good side and she torn on whether to help him as members of his gang arrive at Shiloh and Hicks hires help.
Trampas, Stacey, and Elizabeth are transporting a bull back to Shiloh when they encounter a massive sand storm. They find a deserted homestead to take shelter in while waiting out the storm. While there others start showing up beginning with the Van Owens who are on vacation. Trampas recognizes her as as a crooked dealer from years back with a different name and her husband is the president of the local bank. When the bull knocks a hole in the wall, Trampas and Stacey discover $10,000 in gold coins and wonder who to trust.
Kiley Cheever's father, the sheriff, is fed up with his son's bratty behavior. After publicly humiliating him, Kiley decides to leave Texas and find his old friend Trampas and ask for a job at Shiloh. His personality trait of embellishing his abilities creates tension with the hands at Shiloh. Melissa, niece of the Graingers, visiting Shiloh takes a shine to Kiley while still seeing his flaws and letting him know it. An old hand, Charlie, who knows Kiley's dad takes a shine to Kiley but loses his job when Kiley lets him take the blame for starting a fire in the stable...
Stacey is in a buggy accident with Janie Buell resulting in a broken arm. The broken bones heal but the arm and hand are numb with no feeling or control. Dr. Spaulding calls in a specialist who decides an operation is needed with no guarantee of success. Jamie with encouragement from her mother has developed a serious relationship with Stacey. Mrs. Buell has raised Jamie in an affection-less environment resulting in Jamie unable to handle the potential that Stacey may lose the use of him arm permanently and Stacey losing all hope. Clay calls on The Virginian to help ...
Ward Bowden is pressing his father to fight for total ownership of a strip of land between their ranch and Shiloh that has been shared. When their attorney tells them their case is weak, Ward initiates activities to sway public opinion in their favor. A drifter, Jim, comes to the aid of Trampas when Ward leaves him knocked out on a runaway wagon. One of the Bowden hands recognizes him as a known gunfighter from Virginia City leading the Bowdens to believe Shiloh has upped the ante in the conflict. As the Shiloh handyman, Jim continues to come to the aid of Trampas.
Sheriff Dan Porter leaves his job as sheriff of Mason City to follow his wife to Medicine Bow as she is terrified of him being killed on the job. He signs on as a ranch hand at Shiloh to learn ranching but Trampas has a grudge against him for putting Trampas in jail. He hopes to buy and start his own ranch once he has learned the basics. When a Shiloh cattle drive has to divert to Mason City, he finds the young man he left in charge is not up to the challenge of the job.
While hunting a cougar, Trampas encounters a lost and sick teenager who calls himself Seth. Trampas tends to him and adopts him as an assistant on the rest of the hunt. Although Seth stays with Trampas, he occasionally takes side trips unknown to Trampas. Seth continues to work at Shiloh until the sheriff tracks down his family. Although reluctant to go with his uncle, Seth does. The sheriff learns that the uncle is an outlaw resulting in him and Trampas tracking down Seth and his uncle and learning the truth.
David Sutton is a drifter from the east headed to Medicine Bow. He stops at a homestead for water and meets Saranora who wants him to take her with him but the owner runs David off. In Medicine Bow David is partially responsible for an accident in the saloon resulting in Trampas breaking his leg and David losing his swamper job. David arrives at Shiloh asking to work in place of Trampas as compensation. However, ranch hand Coley never forgives David for Trampas getting hurt as he counted on Trampas to work with him during the wild mustang roundup. Saranora runs away ...
Dan Sheppard and his son Jeremy arrive at Shiloh to photograph the west. Dan learns that an old sweetheart Della Price is a widow with a ranch caught in a bidding war between an oil speculator and the other local ranchers who are afraid of the negative aspects of the oil industry. Unknown to everyone her foreman is working with the oil speculator to cover gambling losses he incurred with the ranch's money. Della tries to rekindle their lost romance while Dan tries to help the Graingers.
Clay Grainger continues to help an old friend, Tim Bradbury, from 20 years ago in Texas who he feels obliged to since Tim went broke due to a drought after buying out Clay's share of their ranch and cattle. Clay went north and became wealthy. Tim has two sons. One, Mike, works for Clay but is unreliable and gambles heavily. The other son, Walt, is industrious but wants to farm to become financially solvent while his father continues to dream of rebuilding his Texas ranch life. Mike becomes involved with rustlers who are hitting Shiloh and adds to the strain in his ...
Ben Oakes is out to kill Trampas for killing his brother during a bank robbery. He tracks a stage he assumes Trampas is on but the stage wrecks killing everyone but Elizabeth who is blinded. She convinces him to help her return to Shiloh but they become lost and horseless until The Virginian finds them. Elizabeth uses Ben as a crutch during her blindness but also falls in love with him. Ben's friend Jed Cooper arrives at Shiloh wounded after a bank robbery and pushes Ben to go through with his plan to kill Trampas.
The Virginian and Trampas are close to the Canadian border delivering cattle and forced to wait at a remote inn for payment. They find the inn managed by an ex-Canadian Louis Boissevain in exile and a his fiancé Suzanne Mayo who scammed Trampas several years earlier for a large amount of money. The Virginian and Trampas find themselves in the midst of an apparent attempt to convince Louis to return to Canada to lead a revolt while Trampas is asked by Suzanne to keep her secret but all is not as it seems.
Rafe Judson, a Shiloh ranch hand, finds himself being mistaken for the outlaw Wally McCullough. When Rafe learns he will lose the option on a ranch he has been saving for, he decides to take advantage of confusion and hold up the stage himself when he learns it be carrying a $10,000 payroll. When Wally and his girlfriend Angie learn what Rafe has done, they decide to confront Rafe and take over his life to escape the law. Rafe finds he has dug a hole for himself, literally.
An anthrax outbreak is killing Shiloh cattle and threatening the neighboring ranches. Grainger ordered a new vaccine for anthrax but the stage coach bringing it is held up. A bounty hunter and his female prisoner show up at Shiloh looking for horses to go after the men who held up the stage. David Sutton and The Virginian go with them to retrieve the vaccine. The journey results in shootouts and a trip through the outlaw town Misadventure while finding and catching up with the outlaws. During the adventure The Virginian and the prisoner develop a relationship.
The Viriginian finds a woman unconscious on a remote mountain trail on the way to visit his friend Jingo. He takes her to Jingo's cabin and they wait for her to recover as no help is available. She wakes up but is slow to communicate and recover her memory. At the same time another visitor arrives with a lame horse asking to stay until his horse can travel again. As the woman recovers she is attracted to The Virginian in a romantic manner but remembers no details.
Dewey Harper the son of a renown black mustang tamer, Ben Harper, returns home from school due to a lack of funds to continue school. At the same time The Virginian and David Sutton arrive at the ranch to buy horses from the owner. However, the horses are stolen from the ranch while David and Ben stand guard. Since the stolen horses cannot be recovered, The Virginian decides to roundup a new group of horses and break them. When Ben learns he is too old to continue breaking horses but his son wants to take his place, he teams up with the suspected horse rustler for the...
Major James Carlton and his wife Nora make a surprise visit to the Graingers. Nora knew Clay in New Orleans three years before he met Holly and is consumed with impressing people with her social status. Nora is pressing her husband to improve his status by military promotions which she feels have come too slow. While visiting, Holly and Nora are taken prisoner by Indians who have left the reservation and are being tracked by the army. The army captures one of the leaders who they believe murdered a soldier. When the attempted trade of the leader for the women is ...
Trampas and David Sutton are sent to Durango to purchase and return with a bull at an auction. After arriving in Durango, David bumps into Martha Carson who is trying to avoid the romantic overtures of the big hulk "Tiny" Morgan. During the encounter Martha asks David to be engaged to her until Tiny who David mistakes for a diminutive store clerk leaves town. The charade turns into a massive problem for both of them as word spreads and Tiny decides to stay for their wedding. Trampas knows Tiny and tries to warn David but ultimately takes advantage of the situation at ...