Stacey is forced to kill a man who tries to rob him. He returns the body to the man's sister who asks Stacey to leave rather than see the Sheriff. She is afraid their younger brother who joins the Shiloh cattle drive will try for revenge.
Sue Ann leads a dull life as the daughter of a homesteader taking care of her father, two young brothers, and their hired hand Joe who would like to marry her. However, she leaves home to see San Francisco but where will she get the money?
Stacey buys a gold watch that may have belonged to his dead dad. It sets him off on a journey to find the truth about his parent's deaths. He meets an orphaned girl who owned the watch and is curious about her parents who she never knew.
The Virginian looks for Stacey in a town where they are to finish up a cattle deal. His search results in finding Stacey in jail found guilty of murder. He is to hang the next morning forcing The Virginian to find the real killer fast.
After holding up the bank, Dell Stetler and his partner hold the Graingers hostage at Shiloh to help their wounded comrade. John is forced to bring the doctor to Shiloh to tend to the man as he and Stacey plot a way to free themselves.
The Virginian is shot crossing a large Texas ranch. The owner taking him in tries to hire him to be his own foreman. The owner likes to make his own rules putting him at odds with his wife over their son and the running of a gauntlet.
Stacey has developed an interest in a girl but her father doesn't approve of him. After dragging Stacey, the father is found shot in the back. When the $300 he was carrying is found in Stacey's saddle bags, Stacey is charged with murder.
An old and successful friend and his daughter from Chicago visit the Graingers. John is surprised when he learns they want to stay in the area. The high society daughter falls in love with Trampas who doesn't know about her secret illness.
Dr. Spaulding decides to hire another doctor to help share the load but he is unsure whether the attractive female doctor he is sent will work out. The Virginian takes a strong interest in her and her problems as she tries to adapt.
Stacey is shanghaied in Medicine Bow to take the place of a cavalry recruit. An inept officer allows two sergeants to keep up the facade that Stacey is a recruit while putting him through inhumane conditions to keep him quiet.
The Virginian travels to Winton to buys oats for Shiloh. He finds himself in the middle of a fight between the farmers and ranchers with the owner of the oats at the core of the fight with a rancher who is a close friend of John Grainger.
Trampas goes to visit Ida Martin and son Joe who he lived with as a child. Having not seen them in a few years he finds their place deserted. When he learns Joe was killed by a posse, he can't believe the reason given for his death.
Trampas tries to make friends with a beautiful girl he spots riding a pinto but she avoids him. Once he learns who she is, he asks her to a dance but her and her family are hesitant. Eventually she agrees to go but old issues haunt her.
John Grainger asks an old friend from Maryland to come to Shiloh to take the rough edges off his grandkids. She does as he asks quite well but is less than popular with the kids and The Virginian. Unknown to them, she has a secret plan.
A nurse comes to Medicine Bow so see if an outlaw Ryker captured might be her brother as they were both orphaned at an early age. When he escapes and is shot, he uses her feelings to get help as Ryker who is attracted to her purses him.
The Virginian, John and Elizabeth goes to Texas where The Virginian is seen by members of a gang whose leader thinks The Virginian is responsible for the death of his brother seven years earlier. Elizabeth is kidnapped to trap him.
After receiving the third letter with his name on a list of people being killed, Trampas decides to learn who is after him. He meets a gunfighter who is on the list. Together they are trying to solve the mystery which involves his ex=wife.
The owner of a ranch next to Shiloh dies leaving his entire estate to a woman who runs a saloon in Wichita. Her and her partner go to Medicine Bow expecting to sell the ranch but she decides to stay on the ranch despite their background.
An old friend of Ryker's settles on a ranch with a new wife and stepson under a new name due to being wanted. Ryker helps him but loses his job when the man confesses to killing a Shiloh hand who was blackmailing him due to his past.
The Virginian rescues a man who has been shot. As he recovers at Shiloh he and the Grainger kids realize the man is a bit different as well as being from England. A private detective looking for him provides a clue to his background.
Bank teller George Foster has told his ex-lawman dad he is a sheriff to make him proud. When his father is to stop by for a two hour visit, Ryker and The Virginian decide to make him Sheriff but they didn't expect the visit to be extended.
The Shiloh cook, Ah Sing, has decided to open a restaurant in Medicine Bow to support the mail order bride he wants. When he applies for a license for the restaurant with the Justice of Peace, Milo Temple, it is denied because he is Chinese. After being jailed for attempting to open the restaurant without a license, he is represented by a local attorney who has become an alcoholic. The case stretches the attorney's abilities to the breaking point.
Clay and Holly Grainger take over for John as a herd from Texas is brought in by Kyle Jackson and his brothers. However, things turn tragic when Trampas discovers the herd is sick and a brother accidentally kills the wife of an ex-lawman.
Trampas is sentenced to hang for a murder he didn't commit. The Virginian and Stacey try to find new evidence while Clay Grainger and the attorney try for a new trial. Meanwhile, a desperate Trampas escapes prison with his cell mate.
Frank returns from prison to find his father crippled after saving Trampas and working at a low level job for Clay Grainger. Frank accepts a job but his attitude toward Trampas and Grainger push him toward getting revenge via rustling.
Drunk, disliked Walter Verig is found murdered by Trampas who sees Doc Baldwin ride away from the body in his buggy. Trampas is first suspected due to a bloody hand but suspicion soon falls on Baldwin. Trampas tries to prove his innocence.
The Virginian returns a man he killed to his crippled father. After helping bury the body, the man has a heart attack. He asks The Virginian to try to bring his daughter back from the Shoshone to inherit his farm - with The Virginian.
Trampas and two hands deliver cattle to a remote Army outpost. Trampas runs into an old friend who is a gunfighter in a nearby town where Trampas must pick up the payment. However, his friend has his eye on killing Trampas for no reason.
Returning to Shiloh, The Virginian has his horse and gun stolen by a man and his hands who have the local town cowered. He meets an old friend in the town who helps convince him to help arrest them after her daughter is injured by them.
The Virginian takes a herd to a town on the border with Canada but the bank is robbed making his bank draft worthless. He tracks the robbers into Canada to recover the $100,000 but they work for the buyer of the beef at his empire.