Garth's rival from Texas buys a ranch near Shiloh with an eye to expand it. Trampas has an eye for his daughter adding to the friction when the rival puts pressure on small ranches to sell out and cuts the water supply to them and Shiloh.
Steve volunteers to hunt a killer mountain lion alone. After losing his supplies, he is helped by a lonely couple. They lost their son to the cat and maimed it. The husband helps Steve who soon learns the cat is not his only enemy.
J. Jimerson Jones is on the same train to Chicago with Garth and Betsy where Garth helps him adjust to city life. Betsy has her first love with a cub reporter and Jones is taken in by a beautiful woman while another tries to protect him.
A failed British rancher returns to Medicine Bow a wealthy man but conflicted by his cowardice in the Army. After learning he won't die from a dog bite and Trampas is taken captive by Indians he is given a second chance to prove himself.
The Virginian recalls his arrival at Shiloh when he went to work for a neighboring ranch that was close to a range war with Shiloh. He is caught in a feud with the foreman causing the fight and falls in love with the girl engaged to him.
Randy, a lonely, distrusting drifter comes to the aid of a child, only to be accused of killing her father. Only Betsy's faith in him prevents harm from coming to him and the young girl he tries to protect from the killers.
Trampas appears to be in the lead for a local girl until an eastern meat packing tycoon who comes to Medicine Bow to take over his new ranch catches her eye. Trampas is the only one against him until the ranchers learn he has tricked them.
An injured Trampas is thought to be a stagecoach robber according to a Sheriff and is reported dead to Shiloh. He is forced to rely on a young Chinese woman for help until a grieving Steve arrives to find he must help rescue Trampas.
Betsy's Chicago visitor has a shaky visit starting with Garth ignoring his wire. Garth wants the ranch deserted to host a secret meeting with an Indian Chief but intruders invade to kill the Chief and further impede the couple's visit.
The Virginian tracks the man who killed a young friend in a bank robbery. He finds the man's wife and young son alone on a run down ranch. Finding they need help, he stays on as a ranch hand but soon finds himself in a misguided situation.
Steve takes the job of foreman at a ranch with a new female owner against the advice of his friends. The job gets rougher after he is forced to shoot a stranger. He then learns why he was hired when he faces murder charges from his boss.
A storm forces Randy to stay with Betsy and three of her friends at a mansion where they spent time in their youth. The host's daughter was killed two years earlier in a fire. The host has gifts and other surprises that put them on edge.
The Virginian helps a neighbor lady when her son is claimed by an actress as her own son. Her friends in Medicine Bow are upset by the actress and her detective friend with their actions but it appears they have an ironclad case.
Trampas wins the job of bringing an injured neighbor's bride to him from Laramie. However, the trip back is filled with problems including a bride with a mind of her own, Indians, potential outlaws, and a surprise at the end for Trampas.
A horse thief's daughter staying at Shiloh is drafted to help an injured Randy who can't walk due to a spinal injury with therapy. Their frosty relationship changes when Randy gives up and her father escapes jail looking to kill Steve.
News that Betsy and Randy found over $900 in gold in a cave on Shiloh brings two men to Shiloh ranch looking for money. One is a government agent looking for a buried cache of bearer bonds. The other is Randy's older brother with a past.
Ryker is offered the job of stopping a small rancher from paying a mortgage. He is too honest to do it but is framed for killing the rancher. He is a good lawman and the sheriff wants him as a deputy but Ryker wants to save his name first.
A family moves nearby with a pretty daughter drawing the attention of Trampas. However, when he pushes her to dance, he learns she has a club foot. This is compounded by the pressure on her brother to support her in lieu of his own life.
Randy finds an abused stallion in need of medical care. He takes the horse to an alcoholic vet who is a loner but the interest of the daughter of a local rancher. The vet works miracles on the horse while horse works miracles on the vet.
An eastern reporter arrives to write a story on the Judge. He has traveled the world and great talent in many areas impressing the men and especially Betsy who falls for him. All is not as it seems when his true intentions are learned.
The Virginian falls in love with a woman who has the heart of every man around. As the two plan their marriage, her sister and father debate whether they should tell The Virginian the truth about her terminal illness and short time left.
A pretty female eastern reporter arriving broke takes a reporter job in Medicine Bow. She digs up an old story on the Brazos Kid to make money but her talent for inflating the truth lands not only The Virginian but the real one in trouble.
A self-important businessman is pushed off a train and found by The Virginian and Steve on a cattle drive across a desert. He is forced to work his way on the drive and learns some lessons about himself and his impact on other's lives.
A boy in an orphanage near Shiloh latches onto Trampas as his father while Trampas is attracted to the woman running the orphanage. Trampas agrees to help the boy but when his father arrives on Shiloh with men chasing him, problems arise.
Steve is asked by a US Marshal to renew an old relationship with a woman who is now believed to be part of the Wade gang. The reluctant Steve goes along with the idea but finds it a hard task made harder when old feelings resurface.
A local miner's son returns to Medicine Bow from college with the technical knowledge and financial backers to reopen his father's silver mine. Due to financial constraints, corners are cut putting people and cattle in danger.
A female attorney comes to Medicine Bow to open her new practice. After a rocky start with The Virginian, he becomes her first client and she proves her ability. Off to a strong start she jumps into a case putting him into danger.
A feud between ranchers and a railroad tycoon result in murder charges against a rancher when the tycoon's son is killed. Ryker and the Judge try to prove his innocence but must rely on a woman who disappears deserted by the murdered man.
A French portrait painter returns from Chicago to Medicine Bow with Betsy and a new widow to paint her. The Judge suspects he is not being truthful but he seems to be the right medicine for the grieving widow as the Judge investigates.
Ryker invites the man who raised him to come to Medicine Bow after being released from 10 years in prison. When Ryker finds Abe has invited his family to join him, he knows there are problems as Shiloh makes a record sized cattle shipment.
Garth along with other ranchers are worried about homesteaders trying to move onto their public range. Garth realizes the land is not fit for farming but the politician leading them is an old friend who has said it is fit for farming.
A rock slide trapping Shiloh cattle gives an old neighbor and onetime friend of Garth the chance for revenge against Garth. Garth is forced to bring in Chinese labors to dig a tunnel but one of the workers is a surprise for The Virginian.