David Sutton takes a job at Shiloh to make up for the work Trampas can't do after being involved in Trampas breaking his leg. He has a hard time fitting in with the other hands while a girl he met earlier tracks him down to help her.
Photographer Dan Sheppard arriving at Shiloh to take pictures of western life finds a neighbor ranch is owned by an old girlfriend. She is in a tug of war between the an oil speculator and the local ranchers afraid of polluted water.
Tim Bradbury wants to recreate the cattle ranch he had in Texas and feels Clay Grainger owes him the help. His son Walt wants to farm instead while his son Mike who works at Shiloh puts the family in financial peril with his gambling.
Elizabeth is blinded by a stagecoach accident. She is found by Ben Oakes who wanted to kill Trampas who had to miss the stage. Ben tries to help her home but becomes lost. After they are found, She is in love with the conflicted Ben.
The Virginian and Trampas are to meet a man on business near the Canadian border. They have to stay over at a remote hotel due to a storm where Trampas finds a woman who robbed him years ago and Metis rebels who are after her fiancé.
Shiloh hand Rafe Judson is mistaken for an outlaw as the two men look identical. When Rafe loses an option on a ranch due to a lack of funds, he decides to take advantage of the situation to rob a stagecoach without taking the blame.
The Shoshone girl Nai'Be returns to Medicine Bow from an eastern school as a young lady but conflicted on her future. Her childhood sweetheart Tza'Wuda is waiting for her as is a conflict with a rancher forcing her tribe to move its camp.
Shiloh and its neighbor's cattle herds are threaten by an outbreak of anthrax. A wounded man and woman wanting horses tell Clay the stage with a vaccine was robbed and they are chasing the outlaw gang so The Virginian and David join them.
Trampas receives an unfriendly reception when the tries to visit an old friend. Once he finally sees Jason, he learns not all is as it seems. They clash over the building of a dam in Nebraska after Trampas learns about an earlier dam.
The Virginian on a rare trip to visit a friend Jingo in a remote valley when he finds a woman unconscious. At Jingo's cabin she recovers from a fear induced catatonic state but with amnesia but thinks The Virginian is her lover.
The Virginian and David are to pick up a herd of horses Shiloh needs for a cattle drive. The horses are stolen from the seller so they must catch and break a new herd but a conflict between a father and his son over his future intervenes.
Clay's old sweetheart Nora and her husband a Major in the Army stop at Shiloh. Nora tries to impress everyone with herself and her down to earth husband. She is willing to put others lives on the line to help her husband win a promotion.
Trampas and David are sent to buy a bull at Durango for Shiloh. The Virginian vouches to Clay that Trampas can be relied on but it is David who finds himself in trouble. He agrees to be engaged to a woman he bumps into on the street.
Gunman Frank Hammel's arrival on the stage upsets people in Medicine Bow who believe he may be after them. Having saved The Virginian's life ten years earlier, The Virginian takes an active role in calming fears and stopping any killing.
David kills a man in self-defense on Shiloh who stole his girlfriend. He is forced to stay at Shiloh as the man's father and brother wait for him in Medicine Bow as Trampas who is in charge encounters unusual problems on the ranch.
The Virginian sees Bill Burden with two other men who are returning money from selling ranchers' herds. The two leave together but the money is stolen and Bill is lynched. The Virginian wants revenge when he is too late to clear Bill.
After a fight with Trampas, David leaves. He finds himself not only robbed of his clothes and horse by bank robbers but arrested for the robbery himself. Trampas who followed to get him to return, finds himself in the same jail cell.
An orphan who lived with the Graingers in Texas 15 years earlier comes through Medicine Bow. He decides to stay and work for them and is very protective of the Graingers but his years away from them have changed him - in a bad way.
Easterner Scott Austin is sent to Shiloh for the summer as a favor to his wealthy father who is a friend of Clay. The hope is that Scott will develop character. With Clay gone the job falls to The Virginian who has his hands full.
A dispute ends with one man dead, the Sheriff unconscious, and the shooter on the run. The Virginian, Trampas, and David catch the shooter with his family. The softhearted David wants to let the shooter go but The Virginian won't go along.
Eileen Linden is visiting for six weeks with her father's friend Clay Grainger. In an agreement with her father, she is to spend the time away from a man she wants to marry. The man shows up at Shiloh with a hidden purpose.
Tramps takes a stage on a trip. During the trip they hear Arapaho may be loose plus two soldiers with a payroll join it. They find the ferryman dead and a man by the body at a water stop. At the ferry crossing there is more trouble.
When Elizabeth is late returning from a ride for dinner and her horse returns alone, the Graingers, The Virginian, and Trampas go looking for her. A storm impedes them until a clue takes them to an abandoned mine that has caved in.
Claire Garson and Nathaniel E. 'Doc' Watson have an act in which Claire appears to read minds. They receive an offer which involves them in going to Medicine Bow. Claire is to "meet" the Graingers and reveal she might be Clay's niece.
Luke Nichols arrives at Shiloh looking for Trampas tracked by bounty hunter Bracken. Luke helped Trampas break out of prison when he was about to hang. Trampas tries to hide him with the widow McCloud who has a heart of stone - at first.
The Virginian meets the loner, Garrison, on the trail and decides to hire him even though he doesn't socialize well with others. When Sam Marish who had a run in with Garrison is killed during a robbery, Garrison is arrested and tried.