The Virginian, John and Elizabeth goes to Texas where The Virginian is seen by members of a gang whose leader thinks The Virginian is responsible for the death of his brother seven years earlier. Elizabeth is kidnapped to trap him.
After receiving the third letter with his name on a list of people being killed, Trampas decides to learn who is after him. He meets a gunfighter who is on the list. Together they are trying to solve the mystery which involves his ex=wife.
The owner of a ranch next to Shiloh dies leaving his entire estate to a woman who runs a saloon in Wichita. Her and her partner go to Medicine Bow expecting to sell the ranch but she decides to stay on the ranch despite their background.
An old friend of Ryker's settles on a ranch with a new wife and stepson under a new name due to being wanted. Ryker helps him but loses his job when the man confesses to killing a Shiloh hand who was blackmailing him due to his past.
The Virginian rescues a man who has been shot. As he recovers at Shiloh he and the Grainger kids realize the man is a bit different as well as being from England. A private detective looking for him provides a clue to his background.
Bank teller George Foster has told his ex-lawman dad he is a sheriff to make him proud. When his father is to stop by for a two hour visit, Ryker and The Virginian decide to make him Sheriff but they didn't expect the visit to be extended.
The Shiloh cook, Ah Sing, has decided to open a restaurant in Medicine Bow to support the mail order bride he wants. When he applies for a license for the restaurant with the Justice of Peace, Milo Temple, it is denied because he is Chinese. After being jailed for attempting to open the restaurant without a license, he is represented by a local attorney who has become an alcoholic. The case stretches the attorney's abilities to the breaking point.
Clay and Holly Grainger take over for John as a herd from Texas is brought in by Kyle Jackson and his brothers. However, things turn tragic when Trampas discovers the herd is sick and a brother accidentally kills the wife of an ex-lawman.
Trampas is sentenced to hang for a murder he didn't commit. The Virginian and Stacey try to find new evidence while Clay Grainger and the attorney try for a new trial. Meanwhile, a desperate Trampas escapes prison with his cell mate.
Frank returns from prison to find his father crippled after saving Trampas and working at a low level job for Clay Grainger. Frank accepts a job but his attitude toward Trampas and Grainger push him toward getting revenge via rustling.
Drunk, disliked Walter Verig is found murdered by Trampas who sees Doc Baldwin ride away from the body in his buggy. Trampas is first suspected due to a bloody hand but suspicion soon falls on Baldwin. Trampas tries to prove his innocence.
The Virginian returns a man he killed to his crippled father. After helping bury the body, the man has a heart attack. He asks The Virginian to try to bring his daughter back from the Shoshone to inherit his farm - with The Virginian.
Trampas and two hands deliver cattle to a remote Army outpost. Trampas runs into an old friend who is a gunfighter in a nearby town where Trampas must pick up the payment. However, his friend has his eye on killing Trampas for no reason.
Returning to Shiloh, The Virginian has his horse and gun stolen by a man and his hands who have the local town cowered. He meets an old friend in the town who helps convince him to help arrest them after her daughter is injured by them.
The Viginian takes a herd of cattle to Montana near the Canadian border for the ranchers in Medicine Bow. He receives the $100,000 for the herd but the bank is robbed where he left the funds. He tracks the robbers into Canada where he learns the real thief is the buyer of the cattle who controls the area and people around him in his own empire. The Virginian devises a sting to recover the funds but not without consequences for others.
A trio of soldiers are transporting a prisoner across Shiloh property when they learn after a run in with Trampas it appears the prisoner has scarlet fever. Elizabeth and Holly Grainger find the prisoner stranded and inadvertently help him escape. The Graingers are concerned with contracting scarlet fever while Trampas helps two of the soldiers who have their own internal feud recapture the prisoner. However, Trampas is plagued with flashbacks of his own history with scarlet fever.
An old friend of Trampas, Jed Matthews, is hired for his gun to come to Medicine Bow by rancher Tom Tallman to fight homesteaders blocking a pass used by the ranchers to take their cattle to market. Tallman has Jed go to work at Shiloh to spy on their plans as the ranchers have differing views on how to handle the problem. Trampas introduces Jed to the sister of a homesteader who falls for Jed forcing him to choose sides in the dispute.
While on a trip Trampas runs into a dog, Ulysses, who leads him to the ailing Joe Keller. Joe asks Trampas to locate his lost niece who is in the town where Trampas is to visit a girl he along with her family. However, Joe does not remember the name or a description of his niece other than the strawberry mark she has on one knee. Complications due to this task severely interrupt Trampas's attempts to see his friend especially when he is caught inspecting multiple knees in his hotel room by her and her family.
Clay decides to take on three convicts on parole to test whether they can be rehabilitated at the urging of a prison warden. The three get off to a rocky start as they are obvious misfits with no experience and one has a bad attitude.
Elizabeth finds the outlaw Jim Dewey shot and about to die from blood loss. Her and Clay bring him back to Shiloh where everyone is gone except them and Holly due to a cattle drive. While they nurse Dewey back to health, the bounty hunter Ben Hicks arrives revealing the outlaw's identity and wanting to take him in preferably dead but they stop him. Elizabeth is persuaded by Jim he really has a good side and she torn on whether to help him as members of his gang arrive at Shiloh and Hicks hires help.
Trampas, Stacey, and Elizabeth are transporting a bull back to Shiloh when they encounter a massive sand storm. They find a deserted homestead to take shelter in while waiting out the storm. While there others start showing up beginning with the Van Owens who are on vacation. Trampas recognizes her as as a crooked dealer from years back with a different name and her husband is the president of the local bank. When the bull knocks a hole in the wall, Trampas and Stacey discover $10,000 in gold coins and wonder who to trust.
Kiley Cheever's father, the sheriff, is fed up with his son's bratty behavior. After publicly humiliating him, Kiley decides to leave Texas and find his old friend Trampas and ask for a job at Shiloh. His personality trait of embellishing his abilities creates tension with the hands at Shiloh. Melissa, niece of the Graingers, visiting Shiloh takes a shine to Kiley while still seeing his flaws and letting him know it. An old hand, Charlie, who knows Kiley's dad takes a shine to Kiley but loses his job when Kiley lets him take the blame for starting a fire in the stable...
Stacey breaks his arm and injures a nerve in his shoulder during an accident with a girl friend. When his recovery is questionable, she abandons him due to family induced emotional constraints, putting Stacey into a deeper depression.
Ward Bowden is pressing his father to fight for total ownership of a strip of land between their ranch and Shiloh that has been shared. When their attorney tells them their case is weak, Ward initiates activities to sway public opinion in their favor. A drifter, Jim, comes to the aid of Trampas when Ward leaves him knocked out on a runaway wagon. One of the Bowden hands recognizes him as a known gunfighter from Virginia City leading the Bowdens to believe Shiloh has upped the ante in the conflict. As the Shiloh handyman, Jim continues to come to the aid of Trampas.
Sheriff Dan Porter leaves his job as sheriff of Mason City to follow his wife to Medicine Bow as she is terrified of him being killed on the job. He signs on as a ranch hand at Shiloh to learn ranching but Trampas has a grudge against him for putting Trampas in jail. He hopes to buy and start his own ranch once he has learned the basics. When a Shiloh cattle drive has to divert to Mason City, he finds the young man he left in charge is not up to the challenge of the job.
While hunting a cougar, Trampas encounters a lost and sick teenager who calls himself Seth. Trampas tends to him and adopts him as an assistant on the rest of the hunt. Although Seth stays with Trampas, he occasionally takes side trips unknown to Trampas. Seth continues to work at Shiloh until the sheriff tracks down his family. Although reluctant to go with his uncle, Seth does. The sheriff learns that the uncle is an outlaw resulting in him and Trampas tracking down Seth and his uncle and learning the truth.