The Virginian, John and Elizabeth goes to Texas where The Virginian is seen by members of a gang whose leader thinks The Virginian is responsible for the death of his brother seven years earlier. Elizabeth is kidnapped to trap him.
After receiving the third letter with his name on a list of people being killed, Trampas decides to learn who is after him. He meets a gunfighter who is on the list. Together they are trying to solve the mystery which involves his ex=wife.
The owner of a ranch next to Shiloh dies leaving his entire estate to a woman who runs a saloon in Wichita. Her and her partner go to Medicine Bow expecting to sell the ranch but she decides to stay on the ranch despite their background.
An old friend of Ryker's settles on a ranch with a new wife and stepson under a new name due to being wanted. Ryker helps him but loses his job when the man confesses to killing a Shiloh hand who was blackmailing him due to his past.
The Virginian rescues a man who has been shot. As he recovers at Shiloh he and the Grainger kids realize the man is a bit different as well as being from England. A private detective looking for him provides a clue to his background.
Bank teller George Foster has told his ex-lawman dad he is a sheriff to make him proud. When his father is to stop by for a two hour visit, Ryker and The Virginian decide to make him Sheriff but they didn't expect the visit to be extended.
The Shiloh cook, Ah Sing, has decided to open a restaurant in Medicine Bow to support the mail order bride he wants. When he applies for a license for the restaurant with the Justice of Peace, Milo Temple, it is denied because he is Chinese. After being jailed for attempting to open the restaurant without a license, he is represented by a local attorney who has become an alcoholic. The case stretches the attorney's abilities to the breaking point.
Clay and Holly Grainger take over for John as a herd from Texas is brought in by Kyle Jackson and his brothers. However, things turn tragic when Trampas discovers the herd is sick and a brother accidentally kills the wife of an ex-lawman.
Trampas is sentenced to hang for a murder he didn't commit. The Virginian and Stacey try to find new evidence while Clay Grainger and the attorney try for a new trial. Meanwhile, a desperate Trampas escapes prison with his cell mate.
Frank returns from prison to find his father crippled after saving Trampas and working at a low level job for Clay Grainger. Frank accepts a job but his attitude toward Trampas and Grainger push him toward getting revenge via rustling.
Drunk, disliked Walter Verig is found murdered by Trampas who sees Doc Baldwin ride away from the body in his buggy. Trampas is first suspected due to a bloody hand but suspicion soon falls on Baldwin. Trampas tries to prove his innocence.
The Virginian returns a man he killed to his crippled father. After helping bury the body, the man has a heart attack. He asks The Virginian to try to bring his daughter back from the Shoshone to inherit his farm - with The Virginian.
Trampas and two hands deliver cattle to a remote Army outpost. Trampas runs into an old friend who is a gunfighter in a nearby town where Trampas must pick up the payment. However, his friend has his eye on killing Trampas for no reason.
Returning to Shiloh, The Virginian has his horse and gun stolen by a man and his hands who have the local town cowered. He meets an old friend in the town who helps convince him to help arrest them after her daughter is injured by them.
The Virginian takes a herd to a town on the border with Canada but the bank is robbed making his bank draft worthless. He tracks the robbers into Canada to recover the $100,000 but they work for the buyer of the beef at his empire.
A trio of soldiers are transporting a prisoner across Shiloh property when they learn after a run in with Trampas it appears the prisoner has scarlet fever. Elizabeth and Holly Grainger find the prisoner stranded and inadvertently help him escape. The Graingers are concerned with contracting scarlet fever while Trampas helps two of the soldiers who have their own internal feud recapture the prisoner. However, Trampas is plagued with flashbacks of his own history with scarlet fever.
Clay tries to prevent a range war between the ranchers and homesteaders who are blocking their path to market. A hothead rancher hires a gunfighter on the sly who happens to be an old friend of Trampas who falls for a homesteader.
Trampas is sent on a trip followed by a couple days to visit a female friend. On the way he is asked by a dying prospector to find his niece who can only be found by birthmark on her leg. The result is trouble with his female friend.
Clay decides to take on three convicts on parole to test whether they can be rehabilitated at the urging of a prison warden. The three get off to a rocky start as they are obvious misfits with no experience and one has a bad attitude.
Elizabeth finds a man shot in the shoulder. Her and Clay return him to Shiloh but the hands are gone. The two plus Holly help the man recover but a bounty hunter arrives looking for his quarry as Elizabeth only sees the good in him.
Trampas, Stacey, and Elizabeth are transporting a bull back to Shiloh when they encounter a massive sand storm. They find a deserted homestead to take shelter in while waiting out the storm. While there others start showing up beginning with the Van Owens who are on vacation. Trampas recognizes her as as a crooked dealer from years back with a different name and her husband is the president of the local bank. When the bull knocks a hole in the wall, Trampas and Stacey discover $10,000 in gold coins and wonder who to trust.
Kiley Cheever's father, the sheriff, is fed up with his son's bratty behavior. After publicly humiliating him, Kiley decides to leave Texas and find his old friend Trampas and ask for a job at Shiloh. His personality trait of embellishing his abilities creates tension with the hands at Shiloh. Melissa, niece of the Graingers, visiting Shiloh takes a shine to Kiley while still seeing his flaws and letting him know it. An old hand, Charlie, who knows Kiley's dad takes a shine to Kiley but loses his job when Kiley lets him take the blame for starting a fire in the stable...
Stacey breaks his arm and injures a nerve in his shoulder during an accident with a girl friend. When his recovery is questionable, she abandons him due to family induced emotional constraints, putting Stacey into a deeper depression.
A legal fight over a strip of land between Shiloh and the Bowden ranch turns nasty. The fight over cools when the Bowdens mistakenly believe Shiloh has hired a gunfighter but turns serious when they learn he is just a simply handy man.
Sheriff Dan Porter leaves his job in Mason City to follow his wife Emily to Medicine Bow as she can't handle the pressure of his job. He signs on at Shiloh to learn ranching so he can start a ranch and new life with his wife.
While hunting a cougar, Trampas catches a sick and starving boy stealing his grub. The boy won't say anything other than his name is Seth. He helps Trampas and returns to Shiloh where he stays until they track down his shady uncle.