Ryker is offered the job of stopping a small rancher from paying a mortgage. He is too honest to do it but is framed for killing the rancher. He is a good lawman and the sheriff wants him as a deputy but Ryker wants to save his name first.
A family moves nearby with a pretty daughter drawing the attention of Trampas. However, when he pushes her to dance, he learns she has a club foot. This is compounded by the pressure on her brother to support her in lieu of his own life.
Randy finds an abused stallion in need of medical care. He takes the horse to an alcoholic vet who is a loner but the interest of the daughter of a local rancher. The vet works miracles on the horse while horse works miracles on the vet.
An eastern reporter arrives to write a story on the Judge. He has traveled the world and great talent in many areas impressing the men and especially Betsy who falls for him. All is not as it seems when his true intentions are learned.
The Virginian falls in love with a woman who has the heart of every man around. As the two plan their marriage, her sister and father debate whether they should tell The Virginian the truth about her terminal illness and short time left.
A pretty female eastern reporter arriving broke takes a reporter job in Medicine Bow. She digs up an old story on the Brazos Kid to make money but her talent for inflating the truth lands not only The Virginian but the real one in trouble.
A self-important businessman is pushed off a train and found by The Virginian and Steve on a cattle drive across a desert. He is forced to work his way on the drive and learns some lessons about himself and his impact on other's lives.
A boy in an orphanage near Shiloh latches onto Trampas as his father while Trampas is attracted to the woman running the orphanage. Trampas agrees to help the boy but when his father arrives on Shiloh with men chasing him, problems arise.
Steve is asked by a US Marshal to renew an old relationship with a woman who is now believed to be part of the Wade gang. The reluctant Steve goes along with the idea but finds it a hard task made harder when old feelings resurface.
A local miner's son returns to Medicine Bow from college with the technical knowledge and financial backers to reopen his father's silver mine. Due to financial constraints, corners are cut putting people and cattle in danger.
A female attorney comes to Medicine Bow to open her new practice. After a rocky start with The Virginian, he becomes her first client and she proves her ability. Off to a strong start she jumps into a case putting him into danger.
A feud between ranchers and a railroad tycoon result in murder charges against a rancher when the tycoon's son is killed. Ryker and the Judge try to prove his innocence but must rely on a woman who disappears deserted by the murdered man.
A French portrait painter returns from Chicago to Medicine Bow with Betsy and a new widow to paint her. The Judge suspects he is not being truthful but he seems to be the right medicine for the grieving widow as the Judge investigates.
Ryker invites the man who raised him to come to Medicine Bow after being released from 10 years in prison. When Ryker finds Abe has invited his family to join him, he knows there are problems as Shiloh makes a record sized cattle shipment.
Garth along with other ranchers are worried about homesteaders trying to move onto their public range. Garth realizes the land is not fit for farming but the politician leading them is an old friend who has said it is fit for farming.
A rock slide trapping Shiloh cattle gives an old neighbor and onetime friend of Garth the chance for revenge against Garth. Garth is forced to bring in Chinese labors to dig a tunnel but one of the workers is a surprise for The Virginian.
After he saves Trampas The Virginian hires a temporary hand full time. He seems to be the ideal hand but a loner until a man and woman are killed in Medicine Bow and he shoots Trampas. Garth realizes there may be two personas to the man.
A lost Betsy finds a man and his son living isolated in the mountains catching and breaking horses. They have a secret history that she tries to keep hidden but events force her and others into actions that may send the man to the gallows.
Ryker receives a clue as to the location of a man he wants for a murder two years ago. He goes on the trail but is forced to guide a young woman looking for her dad but both men may have been killed in an Indian massacre at Cripple Creek.
The Virginian rescues a passenger after they are in an accident near Shiloh but she has amnesia afterwards. He takes a deep interest in her even after she moves in with the local school teacher but her background catches up with them.
Trampas is sent to collect the money from a cattle sale for ranchers at Medicine Bow. He receives the money in cash but events lead to a woman borrowing $1500 of it forcing Trampas and later Ryker to track her to recover the money.
The Virginian hires a man kicked off a cattle drive by the trail boss even though he is half owner of the herd. The herd passing Shiloh is suspected of having Spanish Fever. The man returns to the herd but his immaturity creates problems.
Ryker's chess playing friend's bride he met in San Francisco arrives but unknown to him she has a hidden past she hides with a bottle. At the same time two brothers released from prison visit Ryker wanting revenge for their dead brother.
The naive Randy is tricked into helping rob a bank in Kansas and due to circumstances is accused by a respected sheriff of being involved in the robbery. The Virginian is left on his own to prove Randy's innocence versus the sheriff.
A crusty timber man threatens the ranchers' grazing lands by clear cutting. He and his foreman expect his daughter to marry the foreman but she has second thoughts when a rancher's son shows an interest in her resulting in a killing.
Trampas escorts a murderer back to a town where he knew the sheriff. There is a question of the man's innocence plus Trampas learns the sheriff died in a horse accident two days later. He decides to investigate the questionable stories.
The Virginian goes to Honesty, Wyoming to collect $8000 owed the Judge on a crooked cattle deal. The town is owned and run by the corrupt man who owes the money. The fight over the money spills into a murder charge against the Virginian.
Trampas feeling sorry for an old cowboy and his grandson decides to hire him at Shiloh on his own. The old man complains about the way the other hands do their jobs but his mistakes and accidents proved costly to others and Shiloh itself.
The Virginian arrives in Monolith, Arizona to buy cattle from the Landers family but finds himself in the middle of a feud between them and the city Marshall Frome and his brother. The Fromes seem overbearing but maybe with a reason.it
This episode is a crossover with the Texas Rangers from the show Laredo. Trampas is sent by the Virginian to Mexico to return with a bull purchased by Judge Garth. While in Laredo waiting to cross over into Mexico, Trampas becomes involved in fights with three of the Texas Rangers. He ends up traveling with them into Mexico to recover money stolen from a train and to save a baby found alone on the train. This episode has a strong comedic bent to it.