Granny is worried that Ellie is an old maid at twenty while Jed is concerned about Jethro joining college protesters. They both miss the hills so it's decided the Clampetts are headed to the Ozarks which upsets Mr. Drysdale.
After settling in at Silver Dollar City Jed, Granny, and Ellie greet old friends. Granny meets up with her old rival Elverna Bradshaw and restarts her feud. Jethro continues his college protests back in California.
The family begins to make plans for Elly May's upcoming wedding to Matthew, but Mr. Drysdale finds himself preoccupied during the entire matter by the prospects that the wedding will lead him to lose his biggest account.
After Ellie's wedding plans fall through because Matthew is unavailable, the Clampetts leave Silver Dollar City. They head to New York City where thry encounter their old "friend" conman Shifty Shafer who sells them Central Park.
Honest John continues to show the Clampetts around New York trying to "sell" them as many landmarks as possible. The police have given him a twenty four hour notice while Miss Jane and Mr. Drysdale try to get there to stop the con job.
The Clampetts settle on their new property of Central Park and Jed starts building a log cabin. Granny looks for possums but meets muggers instead giving them a lesson in manners. Mr. Drysdale pleads with them to return to California.
The Clampetts return to their mansion and Mr. Drysdale claims the critter Dr. Graham is perfect for Ellie. But Granny, after breaking her glasses, mistakes a seal for the veterinarian leading to a series of misunderstandings.
Shorty Kellems comes to Beverly Hills for a visit. Mr. Drysdale misunderstands a conversation and mistakenly believes Shorty is wealthier than Jed, and begins to indulge him in every way possible to win his account.
Jethro is leading a wild life with Shorty. Granny is determined to get Shorty to return to the hills. Meanwhile, Mr. Drysdale would like Shorty to invest his money with the bank... enlisting the secretarial pool to persuade him!
Shorty's been sent back to the hills, but the Clampetts still have all his girl boarders to deal with in the mansion; and Mr. Drysdale has serious trouble when Jean Bell's brothers get the mistaken idea that he has enslaved their sister.
Honest John shows up with another scheme to get the Clampett millions for himself. Convincing them he's invented machines to blow the smog away, Jed finds trying to get his money from Mr. Drysdale nearly impossible.