 | Mister Ed | ... | Himself (145 episodes, 1958-1966) |
 | Allan Lane | ... | Mister Ed (145 episodes, 1958-1966) |

| Alan Young | ... | Wilbur Post / ... (144 episodes, 1961-1966) |

| Connie Hines | ... | Carol Post (144 episodes, 1961-1966) |
 | Edna Skinner | ... | Kay Addison (86 episodes, 1961-1964) |
 | Larry Keating | ... | Roger Addison (81 episodes, 1961-1963) |
 | Leon Ames | ... | Gordon Kirkwood (40 episodes, 1963-1965) |
 | Florence MacMichael | ... | Winnie Kirkwood (40 episodes, 1963-1965) |
 | Barry Kelley | ... | Carol's Dad / ... (11 episodes, 1962-1966) |
 | James Flavin | ... | Mr. Kramer / ... (8 episodes, 1961-1965) |

| Jack Albertson | ... | Paul Fenton (6 episodes, 1961-1964) |
 | Joe Conley | ... | Charley Grant / ... (6 episodes, 1961-1965) |
 | Richard Deacon | ... | Doctor / ... (6 episodes, 1961-1964) |
 | Hazel Shermet | ... | Information Clerk / ... (5 episodes, 1961-1965) |
 | Barbara Morrison | ... | Customer / ... (5 episodes, 1961-1965) |
 | Ray Kellogg | ... | Frank / ... (5 episodes, 1962-1966) |
 | Nick Stewart | ... | A Man / ... (5 episodes, 1962-1965) |
 | Henry Corden | ... | Mordini / ... (4 episodes, 1961-1965) |
 | Logan Field | ... | Hogan / ... (4 episodes, 1961-1965) |
 | Frank Wilcox | ... | Dr. Chadkin / ... (4 episodes, 1961-1965) |
 | Richard Reeves | ... | Charley / ... (4 episodes, 1961-1965) |
 | Karl Lukas | ... | Charlie / ... (4 episodes, 1962-1965) |
 | Ben Welden | ... | Joe / ... (4 episodes, 1961-1965) |
 | Robert Nunn | ... | B.J. / ... (4 episodes, 1965) |
 | Lisabeth Field | ... | Bank Teller / ... (4 episodes, 1961-1965) |
 | Al Checco | ... | Joe King / ... (4 episodes, 1961-1963) |
 | Howard Wendell | ... | Mr. Reeves / ... (3 episodes, 1961-1965) |
 | Thomas Browne Henry | ... | Dr. Howard / ... (3 episodes, 1961-1966) |
 | John Qualen | ... | Axel the Handyman / ... (3 episodes, 1961-1965) |
 | Rolfe Sedan | ... | Dr. Robbins / ... (3 episodes, 1961-1965) |
 | Neil Hamilton | ... | Harvey Ainsworth / ... (3 episodes, 1962-1965) |
 | Lee Goodman | ... | Cub Scout Master / ... (3 episodes, 1962-1963) |
 | Hugh Sanders | ... | Detective Hawkins / ... (3 episodes, 1962-1965) |
 | Robert Carson | ... | Mr. Benson / ... (3 episodes, 1962-1963) |
 | George N. Neise | ... | Dr. Pearson / ... (3 episodes, 1964-1965) |

| Donna Douglas | ... | Blanche / ... (3 episodes, 1961-1962) |
 | C. Lindsay Workman | ... | Director / ... (3 episodes, 1962-1965) |
 | Chick Chandler | ... | John McGivney / ... (3 episodes, 1962-1964) |

| Norman Leavitt | ... | Holly / ... (3 episodes, 1962-1964) |
 | Mary Carroll | ... | Mrs. Harkness / ... (3 episodes, 1958-1964) |
 | Don Brodie | ... | Barker / ... (3 episodes, 1961-1965) |
 | Olan Soule | ... | Makeup Man / ... (3 episodes, 1961-1964) |
 | Reed Howes | ... | Harvey Wells / ... (3 episodes, 1961-1962) |
 | Al Roberts | ... | Counterman / ... (3 episodes, 1961-1963) |
 | Bill Baldwin | ... | M.C. / ... (3 episodes, 1962-1965) |
 | Gail De Cossi | ... | Aerialist / ... (3 episodes, 1962-1965) |
 | Jay Ose | ... | Joe Haskell / ... (3 episodes, 1961-1964) |
 | Oscar Beregi Jr. | ... | Kosh (2 episodes, 1965) |
 | George O'Hanlon | ... | George Harper / ... (2 episodes, 1962-1964) |
 | Bobby Diamond | ... | Chuck / ... (2 episodes, 1965-1966) |
 | Peter Leeds | ... | Hal Robbins / ... (2 episodes, 1961-1964) |
 | Eleanor Audley | ... | Aunt Martha (2 episodes, 1961-1965) |
 | Les Tremayne | ... | Dr. Brink / ... (2 episodes, 1961-1965) |
 | Gage Clarke | ... | Mr. Hastings / ... (2 episodes, 1961-1963) |
 | Robert Foulk | ... | Keeper / ... (2 episodes, 1961-1963) |
 | Doris Packer | ... | Emma Hoblock / ... (2 episodes, 1961-1963) |
 | Coleen Gray | ... | Ann / ... (2 episodes, 1961-1962) |
 | Raymond Bailey | ... | Howard Dieterle / ... (2 episodes, 1962-1965) |

| Sharon Tate | ... | Girl / ... (2 episodes, 1963) |
 | Irwin Charone | ... | Capt. Vernon / ... (2 episodes, 1964-1965) |
 | June Whitley Taylor | ... | Mimi Hilliard / ... (2 episodes, 1964-1965) |
 | Ray Walker | ... | Cameraman (2 episodes, 1958-1962) |

| Jack LaLanne | ... | Himself / ... (2 episodes, 1961-1963) |
 | Henry Norell | ... | Dowd / ... (2 episodes, 1961-1962) |
 | Percy Helton | ... | Dr. Evans / ... (2 episodes, 1962-1965) |
 | Robert Patten | ... | Mr. Page / ... (2 episodes, 1963-1965) |

| Butch Patrick | ... | Stevie / ... (2 episodes, 1963-1964) |
 | George Barrows | ... | Brannigan / ... (2 episodes, 1961-1965) |
 | Carole Evern | ... | Secretary / ... (2 episodes, 1961-1962) |
 | Hank Weaver | ... | Master of Ceremonies / ... (2 episodes, 1961-1962) |
 | Robert Anderson | ... | Harry / ... (2 episodes, 1962-1963) |
 | Willard Waterman | ... | Mr. Douglas / ... (2 episodes, 1962-1963) |
 | Benny Rubin | ... | Desk Clerk / ... (2 episodes, 1963-1965) |
 | Henry Brandon | ... | Derek (2 episodes, 1965) |
 | Cordy Clark | ... | Flobelle / ... (2 episodes, 1961) |
 | Herb Vigran | ... | Joe Burke / ... (2 episodes, 1962-1963) |
 | Moyna MacGill | ... | Lady in Library / ... (2 episodes, 1963) |
 | Roger Torrey | ... | 1st Coast Guardsman / ... (2 episodes, 1964-1965) |
 | Michael Ross | ... | Jarvis / ... (2 episodes, 1965) |
 | Chris Hughes | ... | Newsboy / ... (2 episodes, 1961) |
 | Karen Norris | ... | Mother / ... (2 episodes, 1961-1963) |

| Anthony Warde | ... | Policeman / ... (2 episodes, 1961-1963) |
 | Jan Brooks | ... | Mrs. Phillips / ... (2 episodes, 1961-1962) |

| Elvia Allman | ... | Ida Brenner / ... (2 episodes, 1961) |
 | Peter Brooks | ... | Andy / ... (2 episodes, 1962-1964) |
 | Riza Royce | ... | First Guest / ... (2 episodes, 1962-1963) |

| Nobu McCarthy | ... | Mai Ling (2 episodes, 1965) |
 | Michael Monroe | ... | Willie McIntyre / ... (2 episodes, 1961) |

| George Burns | ... | George Burns / ... (2 episodes, 1962-1963) |
 | Ricky Star | ... | Chuck Miller / ... (2 episodes, 1962) |
 | John Hale | ... | Harold Johnson (2 episodes, 1961-1963) |
 | Sheldon Allman | ... | Mister Ed's singing (2 episodes, 1961) |
 | Ginny Tyler | ... | Claudia / ... (2 episodes, 1963-1965) |