An ex-football player turned surgeon is desperate to overcome the signs and pain of severe arthritis, which would end his surgical career, so he decides to try a medicine which has not been approved by the FDA.
A female surfer almost drowns when she falls off her board on a wave. She is diagnosed with petit mal seizures, which will necessitate that she give up surfing. But she feels this is like giving up her life's passion. Kildare is involved in her case, as well as that of the alcoholic young wife of a major hospital benefactor.
Yvette Mimieux as Pat Holmes cannot let her seizures keep her from surfing. She returns to the ocean. Dr. Kildare follows her to stop her, but he is too late. She suffers a seizure while surfing and drowns.
A retired heart surgeon, anxious to feel useful again, is called in as a consultant on a case Kildare is assisting on. Unfortunately, friction develops between him and the younger doctors, and his young grandson, who'd been depending on his grandfather for attention, feels left out.
While an acerbic veteran doctor recuperates from a heart attack, Kildare is assigned to temporarily take over his inner-city clinic. He finds it more difficult than he realized as the patients are reluctant to accept him, and the old doctor keeps trying to get in on the action rather than take time to relax.
A writer comes to Blair Hospital to do research on her next book, and incurs the resentment of Dr. Kildare, who finds her writing on medical issues overly sentimental. He is unaware that she is suffering from a serious illness herself.
In an episode with a comedic touch, an overly persuasive Good Samaritan brings an injured sheepdog into Blair and through her charms persuades Kildare and another doctor to work on him, and a Texas oil millionaire who is brought in insists on anonymity and poses as a nameless vagrant.
After his beloved young granddaughter dies during a routine tonsillectomy, an elderly man, upset by what he perceives as the hospital staff's lack of concern, decides to take action by planting a bomb in Gillespie's office.
After suffering a heart attack, the hard-driving president of a major corporation still refuses to put his health ahead of his business. After a second attack, immediate surgery is indicated, sending the business world into a frenzy and putting pressure on his executive vice-president as well.
Kildare deals with two third-year medical students working under him. One is brilliant in diagnosis but has a carefree attitude and refuses to in any way sacrifice his personal life for hospital duties. The other, his roommate, is on scholastic probation and is so afraid of failing that he becomes overly tense and often jumps too quickly to incorrect diagnoses.
A woman who just lost her husband after a long illness wants to volunteer at Blair to help severely ill patients. She decides to try to give a terminally ill young boy a day of happiness. But she violates procedure in order to do so, not getting true consent from the boy's emotionally distant young stepmother.
A private hospital refuses to admit a little girl in respiratory distress because her mother can't pay and doesn't have insurance. The girl is rushed to Blair, where she dies. After Kildare is overheard saying she might have been saved if not for being refused admittance there, the administrator of the private hospital takes Kildare to court for libel.
Janitor Joe Hogan refuses to have another operation for the cancer he's been battling for several years, because he feels he has no one to live for. But Kildare learns of one person---a girl in the apartment building Joe worked in, who is now dealing with a highly dysfunctional family life.
A young woman is brought into Blair after going into a seizure due to an overdose of amphetamines. She is treated by Kildare and Lois Bower, an intern he is dating. The young patient's boyfriend, who brought her in, is belligerent and uncooperative with Kildare and Lois. Later he and his friends follow the two on their date and attack them on the beach, forcing Kildare to watch as Lois is assaulted.
An eccentric, acerbic author checks himself in at Blair. Despite tests showing him to be in perfect health, he insists that he has a premonition that he is going to die, and refuses to leave the hospital even when it is loaded beyond capacity with victims of an explosion.
The wife of a Blair kitchen worker is brought to the hospital after collapsing at her apartment. She refuses to undergo exploratory surgery to discover the extent of a tumor, telling Kildare that she knows she is going to die. Kildare tries to get her husband to convince her to have the surgery, but this only leads to friction as the man and his wife have had increasing difficulty in communicating with each other due to different outlooks on life.
Working at a camp for diabetic children, Kildare befriends a talented 15-year-old girl who is bitter about her condition and having difficulty adjusting to it. But to her mind the relationship is becoming more than just a friendship
A renowned tropical doctor and his young son are both stricken with a rare fever from an elusive animal. Unfortunately, there is only enough serum available to treat one of them, and Kildare may be the one to decide who gets it.
In the emergency room, a police detective and a particularly aggressive assistant district attorney try to pressure Kildare into allowing them access to one of his patients, a heart attack victim who has only hours to live. They want her to give a deathbed statement implicating her brother-in-law as an accomplice in a murder, but Kildare refuses, as the patient does not know she is dying. What's more, the man they hope her to implicate is also there with the patient's sister, hoping to pressure her against saying anything.
Dr. Max Jurgens is known to his colleagues as "the Iron Chancellor", but his wife sees a gentler side to him. In fact, she wraps her entire life around him. Now he is terminally ill, and fears for how she is going to handle losing him.