While Kildare assists in the case of a pregnant woman who shows a lack of enthusiasm and even hostility to the idea of giving birth to her first child, Gillespie is involved in the case of the hospital's original benefactor, who is suffering from a perforated ulcer.
Kildare and a young intern assist in the field treating victims of a major forest fire. The intern, however, finds himself having a difficult time dealing directly with the victims in life-and-death situations. (Episode broadcast in color as part of network's special color week).
The anti-Western son of the ruler of an Arab nation is found to be suffering from a brain tumor. Doctors at Blair tell him it must be removed surgically and that they believe they can successfully operate, but the young man asks that a Communist-trained surgeon be called in to do it. When the surgeon arrives and talks to the son, he advises him to not have the surgery---for political reasons.
Kildare is assigned to assist in plastic surgery, and a friend of his decides to undergo it to reconstruct the oversize nose she's long been self-conscious of. But her personality change after the operation is not nearly as positive as she and her friends thought it would be.
Kildare works under an orthopedist who, while highly skilled and efficient, is also overly perfectionist and demanding with those who work under him. Especially Kildare, whom he starts to suspect of wanting to undermine him.
Veteran nurse Jenny Freesmith, newly returning to duty after successfully battling morphine addiction, recognizes all the signs in younger nurse Cathy Benjamin and tries to get her to also overcome it. When Cathy steals morphine from the hospital supply room, Jenny plans to take her for cold-turkey withdrawal.
While Kildare is visiting his hometown along with Gillespie, a young mother finds her newborn baby dead in his crib. The longtime coroner quickly rules, without an examination, that the baby suffocated in his blankets, causing the mother to blame herself. Kildare believes that the ruling was premature and that an autopsy should be conducted, causing friction between him, the coroner, and the baby's father.
Kildare finds himself in an ethical dilemma after a severely burned auto accident victim tells him about the medicine he had taken before the crash, information which will likely go against his wife's case when she takes the other driver to court.
Kildare is falling deeply for a young intern who is determined to become the first female surgeon from Blair Hospital. Both of them know, however, that plans to marry and start a family would go against her when the hospital board considers her application.
An egotistical former movie idol is admitted to Blair, and tests can find no reason for her apparent inability to walk. Kildare hopes to determine the problem, and also to encourage the actress to see another patient of his, a girl with terminal cancer who idolizes her. But in pursuing both matters Kildare butts heads with the actress's personal physician.
Kildare volunteers for work in the jail ward after treating two policemen and the assailant who shot them for bullet wounds. One of the policemen dies, and Kildare discovers that the killer may have a blood disorder, requiring that his trial be delayed until he has undergone tests and treatment, which angers the dead officer's partner.
A neurologist is accidentally exposed to an excessive amount of radiation, which will cause him to go blind in a matter of weeks, just as his family is hoping for him to go on a vacation, and as one of his patients is desperate for him to perform surgery to correct her symptoms of Parkinson's disease.
After Kildare saves the life of a young woman who tried to commit suicide by overdosing on barbiturates, the girl's parents (particularly her father) become so worshiping of him that they put him on a pedestal and talk as if he can do no wrong. Kildare finds it hard to tell them that she is still not out of the woods.
After observing that a woman has still been been physically abusing her young daughter, Kildare wants to get involved in the case and report her for it. But this puts him in conflict with the nun who's been assigned to the family's welfare, as she hopes to do everything in her power to keep the girl's family together if possible.
Working with a middle-aged Australian intern from the outback, Kildare is disturbed by the man's disregard for protocol and paperwork---and by his deeply prejudicial attitude toward a patient sent to the hospital from immigration services.
Responding to a call at an apartment where an elderly man has collapsed, Kildare discovers the man's teenage daughter living inside. She has not ventured outside the apartment for years and appears to live in a fantasy world. When her father's condition is determined to be terminal, Kildare tries to determine if and how the girl, who is becoming attached to him, could survive in the real world.
In a lighter episode, Gillespie wins the hospital raffle for a vacation, and goes on a luxury cruise. However, he asks to not be identified as a doctor on the cruise list so that he won't be constantly pestered. But when the ship's doctor learns about his profession anyway, he assumes Gillespie is the spy sent by the ship's owners to investigate his excessive expense account.
A young woman is bitter and cold toward her seriously ill father, until he lapses into an irreversible coma, after which she begs Kildare to do everything possible to keep him alive. This puts Kildare in conflict with the chief resident in charge, who strongly opposes taking extraordinary measures to extend life for hopeless patients.
A brilliant doctor who is also a minister turns down Gillespie's offer of a residency at Blair, preferring instead to join his wife as a missionary in South America. But when struck by a tragedy, his faith is shattered and he reacts bitterly toward attempts by others to help.
Alfred Freely, a cheerful Irishman, comes in to Blair for a check-up, and tells Kildare that he is his long-lost uncle, though Kildare does not really remember him. Because of the man's gift for blarney and cheer, Kildare puts him in a ward regarded as the "jinx ward", due to the fact that several in it have died, and the others need something to lift their spirits. But then Kildare learns that Alfred may be seriously ill himself..
A man suffers a heart attack after coming to see his blind daughter, whom he abandoned when she was a child in order to live a vagabond life. The daughter refuses to forgive him and will not accept his offer of help, nor will she take a chance on surgery to restore her sight, because she has been disappointed by past operations that failed.
While in a state of advanced delirium tremens, an alcoholic tells Kildare that it was he who committed the embezzlement for which his former business partner was convicted and sent to prison. He tells Kildare to tell the police after he dies, but then he recovers and says he was hallucinating when he said it. Kildare is in a dilemma as to whether or not to believe him, or to tell the police.
A little girl is brought to Blair after being found unconscious on the street. She has no identification and no one comes to identify her. On examination no physical reason can be determined for her apparent comatose state. Kildare begins to suspect that she is suffering from a dissociative reaction to some emotional trauma.