Kildare believes that a highly respected older doctor is slowing down too much in surgery, and informs Gillespie of this even though the man is one of Gillespie's oldest friends and mentors. Gillespie must make the decision as to whether to suggest to his friend that he should retire.
Kildare feels that a doctor acted too hastily is releasing a man who is showing some vague but troublesome symptoms. When the man dies the next day, his relatives seek a malpractice suit against the hospital.
When Kildare becomes bothered by the lack of concern some people in the big city show for their fellow humans, Gillespie gives him a few days off to travel to his small home town. While there, he discovers that the fiancée of one of his close friends is addicted to heroin.
A friend of Kildare is in a coma after falling and hitting his head. The man's wife, son, and brother struggle with whether to continue treatment at home or in an institution, and even whether or not life is worth living for him anymore.
A surgeon is diagnosed with a progressive paralytic disease, and fears for how it will affect both his career and his relationship with the woman he wants to marry. Meanwhile, Kildare becomes involved in the case of a young girl suffering from severe asthma attacks.
After his son's arm is paralyzed in an automobile accident, a man adamantly refuses to allow doctors to perform the operation which should restore it to full use. The man's wife unexpectedly died during surgery after another car accident a few years earlier, and he has been overly fearful and distrusting of doctors, hospitals, and surgery ever since.
On Christmas Eve, an alcoholic, bitter, cynical department store Santa Claus is admitted to the hospital. The hospital chaplain is shocked to recognize the man as someone he knew in the past, who has let personal tragedies sink him into his current state of despair.
A young man is admitted to Blair after being stabbed by a street gang. The youth soon exhibits erratic and unpredictable behavior which indicate he is severely paranoid and schizophrenic. However, his parents, particularly his father, refuse to listen to the recommendation of the doctors that he be admitted to a psychiatric hospital.
Dr. Simon Agurski's older brother has been paying for his medical education, delaying his own career as an accountant, and his marriage, in the process. Upset by this sacrifice, Simon announces he will drop his plans to become a pediatrician and take a job with an insurance firm. He reconsiders, but the conflict with his brother continues to escalate.
The hospital administrator, already unpopular with much of the staff, makes things worse by firing an employee he suspects of stealing equipment. Meanwhile, his marriage is also on the rocks as his neglected wife increasingly turns to drinking.
Gillespie's daughter leaves her home in Paris to come to Blair for tests. When she is told she is pregnant, she bitterly and angrily denies it, and tries to jump out a window. A psychiatrist tries to discover the source of her fears.
A woman and a little girl are admitted to the hospital and determined to be suffering from botulism poisoning. A dedicated but overly brash and assertive young pediatrician teams with a public health inspector to find the source of the toxin and prevent an epidemic.
A famous doctor, who has made a name for himself working with the poor people of India, comes to Blair for tests due to a suspected neurological disorder, and also to raise more money for his hospital overseas.
When he makes a serious mistake with one of his patients, Dr. Eddie Moore asks Kildare to cover up for him. When Kildare refuses to do so, Moore tries to manipulate a vulnerable young nurse into taking the blame. Meanwhile, the young nurse's strict supervisor, Mrs. Fain, is surprised to find her husband back home after he abandoned her seventeen years earlier.
Maxwell Keller is admitted to Blair after collapsing from malnutrition at a surgical instrument store. Gillespie recognizes him as a veteran medical researcher who pioneered in attempting to eradicate polio. Keller still does his research now - out of the basement at the apartment he rents. Meanwhile a younger pathologist angers both Gillespie and Kildare by his lack of respect for Keller, and by his actions such as asking another elderly patient for permission to perform his autopsy.
Kildare's rodeo rider cousin Lucky Elcott brings in his son who has been stricken with appendicitis. The boy is fine after surgery, but Kildare then notices symptoms in Lucky which turn out to be from rheumatoid arthritis. He tries to persuade Lucky to quit the rodeo, but is it just for his health, or also because Kildare is embarrassed by his cousin's happy-go-lucky, back-slapping style?
A young woman is admitted to Blair and discovered to be suffering from a subdural hematoma. Fearful of hospitals, she asks to be released, though Kildare tells her she needs to be operated on within days or she will die. Instead of returning to Blair, however, she seeks help from a charlatan who feeds on people's mistrust of the medical profession.
A down-and-out, alcoholic poet is found to be suffering from advanced cirrhosis. Unfortunately, his devoted girlfriend has taken to drink as well, and Kildare hopes he can still save her from the poet's fate.
Kitty, a nurse from Blair General Hospital, is ready to deliver a baby after having had multiple miscarriages in the past. Winona Pine, a woman estranged from her husband, is also giving birth to a baby. When Mrs. Pine states she does not want to keep her newborn, Dr. Kildare gets caught up in a plan to help the baby find a loving home.
A highly tenacious yet compassionate nun is determined to continue her social work at the hospital despite having medical issues herself. When finally admitted, she tries to help her roommate, a woman suffering from bone cancer who stubbornly refuses to let doctors amputate her leg and has become bitter toward God because of her situation.
Dr. Paul Probeck, a recovering alcoholic himself, decides to start an alcohol rehabilitation program at Blair, with Kildare as one of his assistants. However, one of the men they are treating is highly uncooperative and doesn't even give his name. After talking to him Probeck starts to wonder if he may be the son he has never met.
To patch up a disagreement he had with another doctor, Kildare attends a party at the doctor's home. One of the guests is the daughter of a wealthy patient of the doctor's, and she and Kildare find themselves falling in love. But can the relationship really work out?
Kildare is assigned to intern under Dr. Nicholas Keefe, a brilliant, highly driven, and extremely thorough resident who is admired for his skill, but not for his belligerent and inflexible intolerance of any imperfections from interns and staff. It is due to this difficulty that Gillespie turns down Keefe's application for the position of chief resident.
A deaf child is brought into the hospital after accidentally swallowing poison. After his recovery, it is discovered that his deafness is treatable, but his overprotective mother refuses to allow the surgery which could cure him.
Kildare is assigned to work in a psychiatric ward to help treat severely schizophrenic patients with a new experimental drug. He recognizes one of the patients as a brilliant orthopedist. However, when Kildare tells the man's wife about the promising breakthrough, she is less than enthused, as she has given up hope for his recovery, and thinks the hospital is just using her husband as a guinea pig.