Dr. Zorba was originally named Dr. Rosenberg. But ABC insisted his name to be changed because they did not want the character to be Jewish. Creator James E. Moser cast Sam Jaffe to play Zorba with a Yiddish accent to emphasize that the character was meant to be Jewish.
Ben Casey was based on a real-life neurosurgeon, Dr. Allan 'Max' Warner. Dr. Warner later changed his specialty to psychiatry because he believed that his association with the show prevented him from being a board certified neurologist.
According to director Mark Rydell, Vince Edwards had a gambling problem. Edwards demanded to film all of his scenes first so that he could leave the set and go to a racetrack. According to Harry Landers, Edwards also constantly asked the cast and crew for money to gamble with and leave the set for hours at a time.