This became the biggest box office hit for director Kurt Neumann, but he never knew it. He died a month after the premiere, and only a week before it went into general release.
Uncredited producer Robert L. Lippert was able to make additional money from the success of this film. His own company, Regal Films, produced Space Master X-7 which 20th Century Fox used as the cofeature for this film.
In the scene where the fly with Andre Delambre's head and arm is caught in the spider's web, a small animatronic figure with a moving head and arm was used in the spiderweb as a reference for actors Vincent Price and Herbert Marshall. Vincent Price later remembered that filming the scene required multiple takes, because each time he and Herbert Marshall looked at the animatronic figure, with its human head and insect body, they would burst out laughing.