When Comancheros wipes out a small wagon train ahead of them, Chris sends Bill and Duke to check it out. They find a young wounded Comanchero who tell them they are to attacked. Chris' actions cause a mutiny.
Indian captive Caroline Casteel is traded to a man who brings her to the wagon train. She encounters prejudice and hostility from many of the train members. But her biggest hurdle comes when her family, who had long given up hope, arrives.
Madame Delphine Sagittarius asks to be picked by the wagon train at Beaver City. The town is expelling her as a con woman. Charlie is initially against it but when no one else on the train accepts her, he becomes her lone supporter.
Wealthy merchant Martin Gatsby, a man with little room for compassion for others, wants the wagon train to keep rolling and demands that Hale leave Caleb Lefton and his family behind, because the inexperienced Lefton is causing delays.it.
John Augustus in a game of cards with a Chinese merchant wins a beautiful Chinese girl. But when he takes her on the wagon train, other passengers ask Hale to have him and the girl kicked off the train for their "indecent" relationship.
In the midst of a dry spell and desperately in need of water, the wagons stop at Mavis Grant's station, the only source of water for miles. But Miss Grant is a bitter and cold hearted woman who demands an outrageous price for the water.it.
Bill Hawks is caught with three Indian grave robbers being chased by the Indians. He is the only one captured and is to be killed until he and the Chief's daughter fall in love. However, the leading brave has other ideas for her and Bill.
An officer Chris knows is found near the wagon train near death. He tells Chris that a passage in the bible describes him and his commander - Shioh Degnan. Chris returns him to Fort Bannerman to the Army where the truth is revealed.
When the Levy family joins the wagon train, the tranquility becomes less so as the fathers compete in checkers, young sons fight, and son and daughter fall in love. Lastly, a settler who tries to shake down the train to cross his property.
Indians kidnap an elderly lady on the train. They will return her when the train takes the Chief's son to the doctor and cure him. However, some on the train don't want to help. The task becomes harder when they learn what the illness is.
Kurt Davos, a highly respected man, is badly injured while trying to save Florence Hastings trapped in a runaway wagon. Florence, scared of dogs had once tried to kill Kurt's dog, volunteers to live with and care for Kurt, now paralyzed.
Patrick O'Shaughnessy has come to visit his daughter Eve, believing her to be a respectable married woman. Knowing that Eve actually is the popular owner of a saloon, Hawks, Wooster, Duke, and Eve's favorite patrons decide to change Eve.
A Bible-quoting marshal joins the wagon train with his prisoner, a young bank robber whom he claims to be trying to reform. He wants the prisoner to atone for his sins by telling the location of the money he hid from his last holdup.
A woman and three companions in a runaway wagon are rescued by a winemaker and Charlie. They are against the consumption of alcohol and join the wagon train. However, she begins to fall for the winemaker until she learns his trade.
The wagon train finds Sam Darland with orphan boys in an old ghost town. Hale tries to convince Darland that it is not safe to stay in the town, as it in the midst of Indian territory and the leader of the tribe has been on the warpath.
A sea captain traveling west haunted by nightmares from his past is found stranded, injured and drunk by Bill and Charlie. After hearing his story, they help him reach his destination to locate a ghost: a dead sailor that may be alive.
When his wagon falls down a cliff, Davey Baxter's mother is killed, and his arm is crushed. The doctor is unavailable, so Chris is forced to make the decision to amputate. This changes everything for Davey and the girl he plans to marry.
On his way to Fort David, wagon scout Duke Shannon rescues Sgt. Johnny Masters being sent to prison for twenty years; a man caught between two worlds. The world of his ancestors the Cherokee, and the world of his loyalty, the U.S. Army.
Hawks rides to the John Kaylor ranch to buy horses for the train but John just died. His widow Naomi refuses to sell the horses at the price John had promised. Naomi shows no sorrow over her husband's death, only wanting to sell the ranch.
Bitter alcoholic Stevenson Drake develops a dislike for the even tempered John Hollister, a fellow Southerner, when he learns he didn't fight for the Confederacy. He also is bothered by the friendliness between his wife and Hollister.it.
While riding through the desert plains, Duke and Charlie come across a sheriff as he is about to die of a heart attack and his female prisoner, Lily Legend, a childhood sweetheart of Duke who the sheriff is taking to be hanged for murder.
Bella McKavitch wants to kidnap Hale, in order to find out about a gold shipment which she thinks the wagon train is carrying, but her dimwitted sons nab Wooster instead. To keep them from attacking the train, Wooster pretends to be a robber himself with plans for a big bank heist. But he also will have to agree to marry Bella.
When children's dolls are found mutilated in her possession, passengers believe that Sara Proctor is either deranged or practicing witchcraft. Hale slowly arrives at the real story after Sara confides to him about her past in Boston, and her son shows him where he buried even more dolls.
Duke Shannon stops over in the town of High Times, and almost right away gets into a fight with, and accidentally kills, one of the gunmen who are essentially holding the town hostage. Then he finds his horse missing as well. Everyone advises or demands that he leave town, but he decides not to, especially when the only one willing to help him and stand up to the gunmen is a crippled young man who is too liable to get hurt or killed trying to do so.
Hale recalls how Annie Duggan selflessly nursed the elderly couple she worked for until they died of typhoid. Afterward, it was necessary for her to be quarantined for two weeks, but she showed no signs of the disease, and she has agreed to marry Dan Highet, another passenger on the wagon train and the father of two children of his own. Now Dan's little girl has come down with the illness, and Hale must relay to Annie the doctor's devastating news about why so many people she has been close to over the years have died.
The four Hooper brothers are orphaned when their parents are killed in a wagon accident. Hale hopes to find someone to take the boys in, but the only person on the wagon train who is willing to take all four brothers together is spinster Ada Meyers. Charlie, who, we learn, was also orphaned as a child and permanently separated from his own brothers and sisters, is determined that this not be the fate of the four boys whom he has come to care for, so he proposes to Ada himself. But when Ada tells him that she should not accept a proposal unless the man loves her just ...
The Perez family is run out of their town because people believe their daughter Juana is a witch. The family joins the wagon train, and then after Juana's brother Felipe is mauled by a cat, their superstitious father and mother also start to think their daughter may be a witch. Dr. Adam MacKenzie, a doctor with some Indian ancestry, along with his young apprentices, seeks to treat both Felipe and Juana and convince their parents that their beliefs are just superstition.
While scouting in Wyoming territory, Duke is forced by outlaw Tom Tuesday to act as his guide to an important rendezvous in Ruby City, Idaho. Tuesday is going blind from a gunshot wound, and Duke is able to turn the tables on him. But when Tuesday tells the story of his past and his reason for going to Ruby City, Duke realizes he can not leave him for dead and decides to help the man get to his destination after all.
Samuel MacIntosh picks farmer Hamish Browne to marry his daughter Heather, before the two have even met, and gets the young man to sign a contract. But getting them to understand each other may be difficult. Heather is a naive young girl who thinks she can talk to animals, while Hamish is a backwoods boy who cares for his livestock more than for women.
Duke comes upon three women under attack by hostile Indians. They are saved by a man named Blane Wessels who appears on the scene. One of the women, whose husband was killed in the attack, is pregnant and soon to give birth. Unfortunately the Indians are certain to return, so the group finds temporary shelter in an abandoned relay station. Though willing to risk death to fight for the others, Wessels still blames himself for the death of his own wife a few months before, and has become overly cynical and fatalistic, a fact which Duke finds troubling and even ...
Duke and Charlie visit an Army fort to see Duke's friend Clarence Mullins, a minister who was also a lieutenant at the fort. They learn that Mullins was kicked out of the Army for refusing the major's order to massacre a band of Modocs, and that he has now gone into the hostile Modoc territory to preach the Gospel to them. Surprisingly, they find that he has succeeded in his mission. However, Duke also feels that Mullins is overly optimistic about his ability to bring the Modocs and the Army officers together in peace.
Hale is entrusted to deliver a box containing $8,000 to a bank. Young David Garner is determined to steal the box, and he stows along on the wagon train, along with a girl who's in love with him. Following them is a shady man who seems to have some hold over David.
Bill Hawks travels to a desert town to visit an old friend, an Indian who has a ranch there. However, upon arriving on his friend's property, he discovers that it is under the control of the local townspeople, who are drilling for water, and that his friend is nowhere to be seen. The townspeople are unwilling to give him any information, and in fact display outright hostility to him, leading Hawks to suspect that his friend may be in danger or even dead.
Invalid cattle rancher Henry Ludlow is so determined that his daughter Judy not marry young Basque sheepherder Antone Rose that he sells his land and joins the wagon train to head west. When Antone learns of this he joins the wagon train as well to join Judy and marry her. But Ludlow is not telling the full reason for his refusal to let his daughter and Antone be together.
Duke Shannon goes to visit his ranch, Shannon's Glen, which he gave his friend Jim Whitlow a half interest in. Duke finds the Shannon spread now a ranching empire, due mostly to the use of tenant farmers and Jim's ruthless foreman who bullwhips them when they don't produce enough yield. Duke is greatly upset by this and asks Jim to fire the foreman and offer the tenants ownership of their sections, but Jim seems unwilling to do either.
Bill meets young Barnaby West, who claims he is traveling west on foot to Sacramento to see his father, a famous frontiersman. Bill takes a liking to the boy, and invites him to join the wagon train. But he and the others wonder just how much, if any, of young Barnaby's story is really true.