Carla Chaney is in jail awaiting her trial for murder. She has fired or lost multiple attorneys so Perry is given her case. She tells him about proof she didn't commit the murder but even Perry has a hard time believing her story.
A fortune teller tells Pat Keane that she will get married but it will end tragically. She later marries her boss Max Armstead, a client and good friend of Mason's. However, a few weeks later Max dies from an apparent case of poisoning.
Candy Queen Claire Armstrong is in the midst of life changing events. She fires the man who made her business and falls for a gambler she trusts - too much. When her secret recipe is stolen, a casino owner is killed and she is charged.
Van Fowler is an instructor at Perry's alma mater. He is working on his PhD with Dr. Stuart Logan. Logan is taking advantage of Van by claiming credit for their combined work. When Logan is found dead with Van by the body, he is charged.
Diana Carter is assisted from the water after stealing a message in a bottle from her dead aunt's home. She believes the man her aunt married murdered her. Perry must first defend her for theft but when the man is killed, she is charged.
Perry Mason is called in to investigate why an insurance company is near bankruptcy due to excessive claims. He calls in a claimant who appears to be healthy but dies when forced to come in for an exam putting Perry in the hot seat.
Lucas Tolliver asks Perry for a will for his wife-to-be which seems odd. When a dating service contacts Perry about Lucas, Perry looks deeper into his history. Lucas isn't what he says he is and is blamed when his new wife is killed.
Wealthy Ellen Payne is the primary owner of the Wildcats football team. Her husband Burt owns ten percent. He was a successful college player but is now a drunk gambler who causes grief for everyone. When he is killed, she is charged.
Perry successfully defends Louise Selff when she is charged with killing her husband. The pressure of the trial has affected Louise so when strange things happen, it appears she killed him again when it turns out he was still alive.
Pete Griston is a race car driver in a new partnership. After the fact he asked Perry to look it over who discovers problems. When Pete has an accident in a test car, it starts a series of events leading to the murder of his partner.
Susan Wolfe is beaten within an inch of her life while her neighbors sit and do nothing. Her overprotective brother Dave, an L.A. police detective, runs to the apartment to check on his sister and is knocked unconscious as a man is killed.
Perry is asked to help retrieve the granddaughter of a scientist from East Germany which wants him back. During the negotiations a go between is murdered with the wife of the scientist charged so Perry defends her in East Germany.
Dr. Todd Meade works for a company developing a new secret process. The company hires Paul to ensure security for a meeting but the details leak. Meade had worked for the competition so when a man is killed in his lab he is charged.
Victor Montalvo picks up a young lady hitchhiking which results in being blackmailed by her. He is part owner of a storied men's club but a new co-owner is changing the format. When he is killed, Victor is charged and she is a key witness.
Ex-con Tony Polk is given a job playing a TV pirate giving gifts to selected viewers. He arrives at an address where an angry woman answers wanting her money. He fights to leave and an eye witness identifies him as her killer.
Perry is Burger's primary witness against his client Holly Andrews as he ran into her as she left the scene of the crime. Her ex-husband is out to destroy her friends and take their child from her plus the murder was heard on the radio.
Miriam Fielding is charged with poisoning her husband when he is killed in a plane he was piloting. They had a rocky marriage and she suspects him of stealing money from his company. Perry suspects the murder may not be what it appears.
Jim Harrell is an aspiring pro at a golf club who must contend with the current pro Chick Farley who was kicked off the professional circuit for his behavior. Chick is killed with Jim's club after threatening Jim with blackmail.
A cop discovers that an art dealer is selling the stolen painting Sausalito Sunrise. When the cop is found dead in the gallery, Perry defends the dealer and an employee. Paul poses as a truck driver to uncover the real fencing operation.
Cynthia Perkins' musician boyfriend Donald Hobart is charged with killing his sponsor in a small town. Perry and Paul there on other business decide to investigate. Based on their findings he is freed and Cynthia is charged instead.
Lennie Beale is a teenager in a car stripping gang who is caught after Perry's car is stripped. Perry sees something good in Lennie giving him a second chance. When a ringleader of the gang is stabbed to death, Lennie is charged.
Perry is hired to help foster the career of singer Sandy Chester. The man hiring Perry wants his name kept secret. Perry contacts Clete Hawley to do the job but Clete's actions cause him to regret it. Sandy is charged when Clete is killed.
Perry takes a client with questionable jewelry to another client in the building to have the jewelry appraised. Shortly thereafter Gerard Van Ness a partner in the jewelry business is found with a dead body in the trunk of his car.
Ethel Andrews thinks she is about to be married but finds herself accused of stealing $50,000 from her company. On the run she changes identities with another woman who dies in an accident. When Ethel's fiancé is killed, she is charged.
Allan Winford is a small time oil operator working for oil tycoon Jerome Klee whose only goal is money. When Klee decides to delay for 10 years the production of an oil field Winford discovered, he is murdered. Winford is charged.
Perry loses a patent case for Barbara Kramer whose father had died. A missing letter would prove her case but the other side used a sailor who looks like Perry to implicate him in bribery. When the winner is killed Barbara is charged.
Ex-boxer Dennis 'Duke' Maronek tries to protect his girlfriend and thinks he accidentally killed a man. He tells Perry, his lawyer, but refuses to go to the police. When another man is arrested for the murder, Perry is caught in a bind.
General Roger Brandon has been asked by a group to head an anti-corruption committee by the governor to fight George Emory. However, compromising pictures arrive showing Brandon's wife. Brandon visits Emory who is then found killed.
After an incident at a party Greg Stanley goes outside to drive a drunken Danny Shine home. When they arrive at Shine's home, Stanley is arrested for shooting Shine who is dead. The case is difficult to solve due to a baby's kidnapping.
Barry Conrad has become a major star with an oversized ego. At the last moment, he tells his show's producer Jackson Sidemark that he won't be signing a new contract. Conrad, then Sidemark are killed giving Perry two clients back to back.